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dc.contributor.author Kim, Man Sub -
dc.contributor.author Bak, Yesol -
dc.contributor.author Park, Yun Sun -
dc.contributor.author Lee, Dong Hun -
dc.contributor.author Kim, Jung Hee -
dc.contributor.author Kang, Jeong Woo -
dc.contributor.author Song, Hyuk-Hwan -
dc.contributor.author Oh, Sei-Ryang -
dc.contributor.author Yoon, Do Young -
dc.date.accessioned 2018-01-25T01:13:08Z -
dc.date.available 2018-01-25T01:13:08Z -
dc.date.created 2017-04-10 -
dc.date.issued 2013-08 -
dc.identifier.issn 0742-2091 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/5305 -
dc.description.abstract Wogonin is a flavonoid compound extracted from Scutellaria baicalensis and is well known as a benzodiazepine receptor ligand with anxiolytic effects. Many recent studies have demonstrated that wogonin modulates angiogenesis, proliferation, invasion, and tumor progress in various cancer tissues. We further explored the mechanism of action of wogonin on cervical cancer cells that contain or lack human papillomavirus (HPV) DNA. Wogonin was cytotoxic to HPV 16 (+) cervical cancer cells, SiHa and CaSki, but not to HPV-negative cells. We demonstrated that wogonin induced apoptosis by suppressing the expressions of the E6 and E7 viral oncogenes in HPV-infected cervical cancer CaSki and SiHa cells. The modulation of p53 and protein retinoblastoma (pRb) were also triggered by the suppression of E6 and E7 expressions. However, p53 was not altered in HPV-negative cervical cancer C33A cells. Moreover, wogonin modulated the mitochondrial membrane potential and the expression of pro- and anti-apoptotic factors such as Bax and Bcl-2. Wogonin also provoked the cleavage of caspase-3, caspase-9, and poly ADP ribose polymerase. After transfection of siRNAs to target E6 and E7, additional restoration of p53 and pRb was not induced, but processing of caspases and PARP was increased compared with wogonin treatment alone. Together, our findings demonstrated that wogonin effectively promotes apoptosis by downregulating E6 and E7 expressions and promoting intrinsic apoptosis in human cervical cancer cells. © 2013 Springer Science+Business Media Dordrecht. -
dc.publisher Springer -
dc.title Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells -
dc.type Article -
dc.identifier.doi 10.1007/s10565-013-9251-4 -
dc.identifier.scopusid 2-s2.0-84883252571 -
dc.identifier.bibliographicCitation Cell Biology and Toxicology, v.29, no.4, pp.259 - 272 -
dc.subject.keywordAuthor Apoptosis -
dc.subject.keywordAuthor Antitumor -
dc.subject.keywordAuthor Cervical cancer -
dc.subject.keywordAuthor Flavonoid -
dc.subject.keywordPlus HUMAN-PAPILLOMAVIRUS TYPE-16 -
dc.subject.keywordPlus SCUTELLARIA-BAICALENSIS -
dc.subject.keywordPlus MEDIATED APOPTOSIS -
dc.subject.keywordPlus CARCINOMA CELLS -
dc.subject.keywordPlus DOWN-REGULATION -
dc.subject.keywordPlus IN-VIVO -
dc.subject.keywordPlus P53 -
dc.subject.keywordPlus DEATH -
dc.subject.keywordPlus RECEPTOR -
dc.subject.keywordPlus IMMORTALIZATION -
dc.citation.endPage 272 -
dc.citation.number 4 -
dc.citation.startPage 259 -
dc.citation.title Cell Biology and Toxicology -
dc.citation.volume 29 -
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