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The ascending reticular activating system from pontine reticular formation to the thalamus in the human brain

Title
The ascending reticular activating system from pontine reticular formation to the thalamus in the human brain
Authors
Yeo, Sang SeokChang, Pyung HunJang, Sung Ho
Issue Date
2013-07-25
Citation
Frontiers in Human Neuroscience, 7
Type
Article
Article Type
Article
Keywords
AdultAscending Reticular Activating SystemBrain FunctionBrain RegionBrain StemConsciousnessControlled StudyDiffusion Tensor ImagingElectroencephalogramFemaleFractional AnisotropyHumanHuman ExperimentImage AnalysisLeft HemisphereMaleMean DiffusivityMental PerformanceNervous System ParametersNeuroimagingNormal HumanPons Reticular FormationReticular FormationRight HemisphereStimulus ResponseTask PerformanceTegmentumThalamus
ISSN
1662-5161
Abstract
Introduction: Action of the ascending reticular activating system (ARAS) on the cerebral cortex is responsible for achievement of consciousness. In this study, we attempted to reconstruct the lower single component of the ARAS from the reticular formation (RF) to the thalamus in the normal human brain using diffusion tensor imaging (DTI). Methods: Twenty six normal healthy subjects were recruited for this study. A 1.5-T scanner was used for scanning of diffusion tensor images, and the lower single component of the ARAS was reconstructed using FMRIB software. We utilized two ROIs for reconstruction of the lower single component of the ARAS: the seed ROI - the RF of the pons at the level of the trigeminal nerve entry zone, the target ROI - the intralaminar nuclei of the thalamus at the level of the commissural plane. Results: The reconstructed ARAS originated from the pontine RF, ascended through the mesencephalic tegmentum just posterior to the red nucleus, and then terminated on the intralaminar nuclei of the thalamus. No significant differences in fractional anisotropy, mean diffusivity, and tract number were observed between hemispheres (P>0.05) Conclusion: We reconstructed the lower single component of the ARAS from the RF to the thalamus in the human brain using DTI. The results of this study might be of value for the diagnosis and prognosis of patients with impaired consciousness. © 2013 Yeo, Chang and Jang.
URI
http://hdl.handle.net/20.500.11750/5306
DOI
10.3389/fnhum.2013.00416
Publisher
Frontiers Research Foundation
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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