Dehalogenative deuteration of alkyl and aryl bromides by thiyl radical catalysis under visible-light irradiation

Abstract

Herein, we report a mild and practical method for the deuteration of alkyl and aryl bromides by a thiyl radical catalyst and halogen-atom transfer (XAT) using disulfides and silanes under visible-light irradiation. In this study, various organic bromides such as 1 degrees, 2 degrees, and 3 degrees-alkyl bromides and aryl bromides were converted to deuterated products in good to excellent yields and D-incorporation. Herein, we report a mild and practical method for the deuteration of alkyl and aryl bromides by a thiyl radical catalyst and halogen-atom transfer (XAT) using disulfides and silanes under visible-light irradiation.