Phosphatidylserine: paving the way for a new era in cancer therapies

Abstract

Lipid phosphatidylserine (PS) plays a vital role in the growth and proliferation of cancer cells and has been identified as a potential target for cancer treatment. Recent studies have focused on using phosphatidylserine-targeting agents in the treatment of several classes of cancer, such as breast, lung, and prostate. The use of PS-targeting antibodies to target cancer cells while leaving healthy cells unharmed is selective. These antibodies are specifically targeted to phosphatidylserine molecules located on the exterior membrane of cancer cells, triggering a series of events that ultimately destroy the cancer cells. In addition, incorporating phosphatidylserine into the liposome membrane specifically targets cancer cells, thereby enabling more efficient drug delivery and improving cancer treatment outcomes. In general, PS has active ingredients that are currently undergoing clinical trials for potential use in treating various types of cancer. On the role of phosphatidylserine in biophysical and cancer biology, this review summarizes recent studies, as well as related prospective clinical and preclinical trials such as immunotherapy and biomarkers. A new indication of future PS implementation in cancer therapy appears to be a new era. © 2024 RSC.