Title

Extra-nasal odorant receptors regulate the progression of glioblastoma

Alternative Title

비강 외 후각 수용체들의 교모세포종 진행 조절

DGIST Authors

Jae Won Hwang ; JaeHyung Koo ; Il-Kyu Choi

Advisor

구재형

Co-Advisor(s)

Il-Kyu Choi

Issued Date

2024

Awarded Date

2024-08-01

Citation

Jae Won Hwang. (2024). Extra-nasal odorant receptors regulate the progression of glioblastoma. doi: 10.22677/THESIS.200000806490

Type

Thesis

Description

Glioblastoma, Tumor-associated microglia and macrophages, Odorant receptors, Ligand

Table Of Contents

Ⅰ. INTRODUCTION 1
ⅠⅠ. MATERIALS AND METHODS 7
IⅠⅠ. RESULTS
3.1 The pathophysiological role of OR5V1 in GBM 12
3.1.1 To establish GL261-luc syngeneic mouse model 12
3.1.2 To demonstrate the function of OR5V1 in GBM 14
3.1.3 To investigate the function of microglial-specific OR5V1 in GBM 16
3.1.4 To determine the anti-tumor effect of OR5V1’s agonist in GBM 20
3.2 The pathophysiological role of OR51E2 in GBM 25
3.2.1 To demonstrate the function of OR51E2 in GBM 25
ⅠV. DISCUSSION 29
V. REFERENCES 36

URI

http://hdl.handle.net/20.500.11750/57607
http://dgist.dcollection.net/common/orgView/200000806490

DOI

10.22677/THESIS.200000806490

Degree

Master

Department

Department of New Biology

Publisher

DGIST

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