WEB OF SCIENCE
SCOPUS
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 정영태 | - |
| dc.contributor.author | Jeongmin Kim | - |
| dc.date.accessioned | 2025-01-20T23:41:13Z | - |
| dc.date.available | 2025-01-20T23:41:13Z | - |
| dc.date.issued | 2024 | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/57608 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000798027 | - |
| dc.description | Keap1, Natural Killer cells, Organoid, Co-culture, Cytotoxicity | - |
| dc.description.tableofcontents | Ⅰ. Introduction 1 1.1 Cancer and immunosurveillance 1 1.2 Cancer immunotherapy 2 1.3 Natural Killer cells 4 1.4 KEAP1 protein 5 Ⅱ. Materials and Methods 7 2.1 Mouse NK cells isolation and culture 7 2.2 Organoid and on-top seeded P/K-LUAD organoid culture 8 2.3 RT-qPCR of Keap1, Granzyme B and Perforin 1 9 2.4 IFN-γ production assay 10 2.5 Fluorescence In Vitro imaging 11 2.6 Cytotoxicity assay 11 2.7 statistical analysis 12 Ⅲ. Result 13 3.1 Isolation murine NK cells 13 3.2 Assessment of Granzyme B, Perforin1 and IFN-γ expression level 13 3.3 Establishment of on-top seeded P/K-LUAD organoids 14 3.4 Evaluation of NK cells’ cytotoxicity 15 3.5 Keap1 deletion enhances NK cell cytotoxicity with cytotoxic molecules 16 Ⅳ. Discussion 23 Reference 27 요약문 32 |
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| dc.format.extent | 32 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.title | Keap1 regulates NK cells’ cytotoxicity in lung adenocarcinoma | - |
| dc.title.alternative | 폐 선암에서 Keap1 조절을 통한 자연 살해 세포의 세포 독성 향상 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/THESIS.200000798027 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Department of New Biology | - |
| dc.identifier.bibliographicCitation | Jeongmin Kim. (2024). Keap1 regulates NK cells’ cytotoxicity in lung adenocarcinoma. doi: 10.22677/THESIS.200000798027 | - |
| dc.contributor.coadvisor | Il-Kyu Choi | - |
| dc.date.awarded | 2024-08-01 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.NM 김74 202408 | - |
| dc.date.accepted | 2024-07-24 | - |
| dc.contributor.alternativeDepartment | 뉴바이올로지학과 | - |
| dc.subject.keyword | Keap1, Natural Killer cells, Organoid, Co-culture, Cytotoxicity | - |
| dc.contributor.affiliatedAuthor | Jeongmin Kim | - |
| dc.contributor.affiliatedAuthor | Youngtae Jeong | - |
| dc.contributor.affiliatedAuthor | Il-Kyu Choi | - |
| dc.contributor.alternativeName | 김정민 | - |
| dc.contributor.alternativeName | Youngtae Jeong | - |
| dc.contributor.alternativeName | 최일규 | - |
| dc.rights.embargoReleaseDate | 2029-08-31 | - |
