WEB OF SCIENCE
SCOPUS
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 정영태 | - |
| dc.contributor.author | Seongsoo Kim | - |
| dc.date.accessioned | 2025-01-21T09:48:26Z | - |
| dc.date.available | 2025-01-21T09:48:26Z | - |
| dc.date.issued | 2024 | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/57646 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000799197 | - |
| dc.description | FAT1, HNSCC, Autophagy, Mitochondria, Stress, Apoptosis | - |
| dc.description.tableofcontents | 1. Introduction 1 1.1. Development of HNSCC 1 1.2. FAT1 2 1.3. FAT1 in diverse cancer 4 1.3.1. Tumor suppressor 4 1.3.2. Tumor promoter 5 1.4. FAT1 in HNSCC 6 1.4.1. FAT1 as a biomarker of HNSCC 6 1.4.2. FAT1 as a potential tumor suppressor gene 6 1.4.3. FAT1 as a potential tumor promoter gene 7 1.5. Development of Autophagy 8 2. Materials and methods 11 2.1. Cell lines 11 2.2. Small interfering RNA 11 2.3. Cell proliferation assay 12 2.4. Colony formation assay 13 2.5. Wound scratch assay 13 2.6. Western blot assay 13 2.7. Antibodies 14 3. Results 16 3.1. FAT1 silencing inhibits cell proliferation and colony formation of HNSCC 16 3.2. FAT1 silencing inhibits cell migration of HNSCC 16 3.3. FAT1 silencing attenuates ULK1 dependent autophagy in HNSCC 17 3.4. FAT1 silencing induces mitochondria dysfunction and leads to HNSCC apoptosis 18 4. Discussion 29 References 33 요 약 문 36 |
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| dc.format.extent | 36 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.title | FAT1 regulates head and neck cancer proliferation and migration via autophagy and mitochondrial dysfunction | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/THESIS.200000799197 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Department of New Biology | - |
| dc.identifier.bibliographicCitation | Seongsoo Kim. (2024). FAT1 regulates head and neck cancer proliferation and migration via autophagy and mitochondrial dysfunction. doi: 10.22677/THESIS.200000799197 | - |
| dc.contributor.coadvisor | Chang-Hun Lee | - |
| dc.date.awarded | 2024-08-01 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.NM 김54 202408 | - |
| dc.date.accepted | 2024-07-24 | - |
| dc.contributor.alternativeDepartment | 뉴바이올로지학과 | - |
| dc.subject.keyword | FAT1, HNSCC, Autophagy, Mitochondria, Stress, Apoptosis | - |
| dc.contributor.affiliatedAuthor | Seongsoo Kim | - |
| dc.contributor.affiliatedAuthor | Youngtae Jeong | - |
| dc.contributor.affiliatedAuthor | Chang-Hun Lee | - |
| dc.contributor.alternativeName | 김성수 | - |
| dc.contributor.alternativeName | Youngtae Jeong | - |
| dc.contributor.alternativeName | 이창훈 | - |
| dc.rights.embargoReleaseDate | 2029-08-31 | - |
