ECoGScope: An integrated platform for real-time Electrophysiology and fluorescence imaging

Abstract

In this study, we present ECoGScope, a versatile neural interface platform designed to integrate multiple functions for advancing neural network research. ECoGScope combines an electrocorticography (ECoG) electrode array with a commercial microendoscope, enabling simultaneous recording of ECoG signals and fluorescence imaging. The electrode array, constructed from highly flexible and transparent polymers, ensures conformal contact with the brain surface, allowing unobstructed optical monitoring of neural activity alongside electrophysiological recordings. A key innovation is the compact connection module, which securely integrates the ECoG array and microendoscope while minimizing interference with animal behavior. The device was successfully tested in the visual, somatosensory, and frontal cortex, demonstrating its capability for simultaneous electrophysiological and fluorescent measurements. These results highlight the potential of the ECoGScope platform to advance the development of multifunctional tools for studying brain function and addressing neurological disorders. © 2025 The Authors