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Exploring the effect of arginine methylation on RNA-regulated FUS LLPS
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dc.contributor.advisor 이종찬 -
dc.contributor.author Dorjrentsen Sugarjav -
dc.date.accessioned 2025-02-28T21:01:37Z -
dc.date.available 2025-02-28T21:01:37Z -
dc.date.issued 2025 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/58012 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200000828334 -
dc.description FUS, LLPS, RNA, arginine methylation -
dc.description.tableofcontents Ⅰ. Introduction 1
Ⅱ. Materials and Methods 5
Ⅲ. Results 10
3.1 Validation of wild-type FUS (FUSWT) fused with fluorescent protein constructs 10
3.2 RNA depletion within FUS granules impairs their ability to assemble in cellular environment 14
3.3 Investigation of the arginine methylation in the RGG1 and RGG2 regions of FUS on its LLPS 17
Ⅳ. Discussion 23
4.1 Cellular stressors and FUS mislocalization 23
4.2 The role of RNA within FUS LLPS in cellular environments 24
4.3 Arginine methylation and its hydrophobicity at the RGG1 and RGG2 regions in FUS-RNA interactions 24
Supplementary information 26
References 33
요약문 (Abstract in Korean) 38
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dc.format.extent 38 -
dc.language eng -
dc.publisher DGIST -
dc.title Exploring the effect of arginine methylation on RNA-regulated FUS LLPS -
dc.type Thesis -
dc.identifier.doi 10.22677/THESIS.200000828334 -
dc.description.degree Master -
dc.contributor.department Department of New Biology -
dc.identifier.bibliographicCitation Dorjrentsen Sugarjav. (2025). Exploring the effect of arginine methylation on RNA-regulated FUS LLPS. doi: 10.22677/THESIS.200000828334 -
dc.contributor.coadvisor Byung-Hoon Lee -
dc.date.awarded 2025-02-01 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.NM D699 202502 -
dc.date.accepted 2025-01-20 -
dc.contributor.alternativeDepartment 뉴바이올로지학과 -
dc.subject.keyword FUS, LLPS, RNA, arginine methylation -
dc.contributor.affiliatedAuthor Dorjrentsen Sugarjav -
dc.contributor.affiliatedAuthor Jong-Chan Lee -
dc.contributor.affiliatedAuthor Byung-Hoon Lee -
dc.contributor.alternativeName Dorjrentsen Sugarjav -
dc.contributor.alternativeName Jong-Chan Lee -
dc.contributor.alternativeName 이병훈 -
dc.rights.embargoReleaseDate 2030-02-28 -
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