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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 남창훈 | - |
| dc.contributor.author | Jin-Woong Heo | - |
| dc.date.accessioned | 2025-02-28T21:01:40Z | - |
| dc.date.available | 2025-02-28T21:01:40Z | - |
| dc.date.issued | 2025 | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/58015 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000841459 | - |
| dc.description | cellular senescence, vutiglabridin, Paraoxonase2, mitochondria, metabolism | - |
| dc.description.tableofcontents | Ⅰ. Introduction 1 Ⅱ. Materials and Methods 6 2.1 Cell culture 6 2.2 Cell growth assay 6 2.3 Senescence Associated-β-galactosidase (SA-β-gal) assay 7 2.4 RNA extraction and cDNA synthesis 8 2.5 Quantitative real-time PCR 8 2.6 Extracellular Flux assays 9 2.7 Confocal microscopy and Electron microscopy 10 2.8 Western blot 11 2.9 NAD+ and NADH measurement 12 2.10 Cell viability assay 13 2.11 Senescence induction in LO2 cells 14 2.12 generation of PON2 Knock-Down cells 14 Ⅲ. Results 15 3.1 Vutiglabridin treatment alleviates replicative senescence of HDFs 15 3.2 Long-term culture with vutiglabridin reduces mitochondrial dysfunction in high-passage HDFs 20 3.3 Long-term culture with vutiglabridin modulates the expression of the metabolic regulatory protein in high-passage HDFs 27 3.4 Treatment of low concentration hydrogen peroxide provokes ROS-induced senescence in L02 hepatocytes 30 3.5 Vutiglabridin alleviates ROS-induced senescence in LO2s with mitochondria morphological change 35 Ⅳ. Discussion 41 Ⅴ. Reference 44 |
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| dc.format.extent | 55 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.title | Vutiglabridin alleviates cellular senescence phenotypes with enhanced mitochondrial function and metabolic changes | - |
| dc.title.alternative | 뷰티글라브리딘은 세포 노화를 감소시키고 미토콘드리아 기능을 증가시키며 노화 세포 내 대사를 변화시킨다 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/THESIS.200000841459 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Department of New Biology | - |
| dc.identifier.bibliographicCitation | Jin-Woong Heo. (2025). Vutiglabridin alleviates cellular senescence phenotypes with enhanced mitochondrial function and metabolic changes. doi: 10.22677/THESIS.200000841459 | - |
| dc.contributor.coadvisor | Young-Sam Lee | - |
| dc.date.awarded | 2025-02-01 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.NM 허78 202502 | - |
| dc.date.accepted | 2025-01-20 | - |
| dc.contributor.alternativeDepartment | 뉴바이올로지학과 | - |
| dc.subject.keyword | cellular senescence, vutiglabridin, Paraoxonase2, mitochondria, metabolism | - |
| dc.contributor.affiliatedAuthor | Jin-Woong Heo | - |
| dc.contributor.affiliatedAuthor | Chang-Hoon Nam | - |
| dc.contributor.affiliatedAuthor | Young-Sam Lee | - |
| dc.contributor.alternativeName | 허진웅 | - |
| dc.contributor.alternativeName | Chang-Hoon Nam | - |
| dc.contributor.alternativeName | 이영삼 | - |
| dc.rights.embargoReleaseDate | 2026-02-28 | - |
