Cited 0 time in webofscience Cited 0 time in scopus

류마티스관절염의 시스템 생물학적 접근

Title
류마티스관절염의 시스템 생물학적 접근
Translated Title
Systems Approach to Rheumatoid Arthritis
Authors
김기조황대희김완욱
DGIST Authors
황대희
Issue Date
2013-12
Citation
대한류마티스학회지, 20(6), 348-355
Type
Article
Keywords
Systems biologyNetwork medicineRheumatoid arthritis
ISSN
2093-940X
Abstract
Phenotypic characteristics of complex diseases such as rheumatoid arthritis are a consequence of interactions of genetic and environmental factors. Biomolecules closely interact with other molecular components and form functional modules, resulting in significant biologic action capability. While traditional biochemical research focuses on a single disease using narrowly constrained data, systems biology aims to interpret large volumes of highly complex and multilevel data obtained from high-through-put technologies to understand how biological systems function as a whole. Such a systems approach to complex diseases, so-called network medicine, can shape our comprehensive understanding of disease mechanisms by identifying modules temporally and spatially perturbed in the context of health and diseases. Given the unmet needs for diagnosis, monitoring, and treatment in rheumatoid arthritis, systems biology is obviously an emerging powerful tool to gain insight into disease mechanisms, study comorbidities, analyze therapeutic drugs and their targets, and discover novel network-based biomarkers.
URI
http://hdl.handle.net/20.500.11750/5905
DOI
10.4078/jrd.2013.20.6.348
Publisher
대한류마티스학회
Related Researcher
  • Author Hwang, Daehee Systems Biology and Medicine Lab
  • Research Interests Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
Files:
There are no files associated with this item.
Collection:
Department of New BiologySystems Biology and Medicine Lab1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE