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히알루론산 마이크로니들 형태에 따른 특성 분석

Title
히알루론산 마이크로니들 형태에 따른 특성 분석
Translated Title
Analysis of Hyaluronic Acid Microneedle Characteristics as Its Shapes
Authors
류종훈신현영이정건태기식김민석
DGIST Authors
김민석
Issue Date
2018
Citation
의공학회지, 39(1), 30-35
Type
Article
Keywords
Dissolving microneedleHyaluronic acidmicroneedle shapeSkin permeabilityDissolution rate
ISSN
1229-0807
Abstract
Conventional drug delivery methods mainly include subcutaneous injection and oral administration. Subcutaneous injection has the advantages of delivering the correct concentration, but it might cause pain and trauma to patients. Although oral administrations do not accompany pain as the subcutaneous injection, unexpected side effects may occur because they undergo digestion process and it is not easy for many drugs to be exposed to targeted sites with proper concentration. While dissolving microneedles have been extensively studied to overcome the limitations of conventional subcutaneous injection, the effects on microneedle shapes for drug release have not been fully explored. In this study, the characteristics of hyaluronic acid microneedles for cone and quadrangular pyramidal shapes were examined by the size, volume, contact surface area, skin permeability, and dissolution rate. As a result, the cone shapes of hyaluronic acid microneedles had high skin permeability, and the quadrangular pyramid of shapes hyaluronic acid microneedles showed a fast dissolution rate, given by the large contact area on the skin. Based on the results, we could confirm that the shape of a dissolving microneedles can affect skin permeability and the drug delivery rate.
URI
http://hdl.handle.net/20.500.11750/5921
Publisher
대한의용생체공학회
Related Researcher
Files:
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Collection:
Department of New BiologyBioDr. Lab - Nanobiomedicine1. Journal Articles


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