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The imprint of salivary secretion in autoimmune disorders and related pathological conditions

Title
The imprint of salivary secretion in autoimmune disorders and related pathological conditions
Authors
Bhattarai, K.R.Junjappa, R.Handigund, M.Kim, Hyung RyongChae, H.-J.
DGIST Authors
Kim, Hyung Ryong
Issue Date
2018-04
Citation
Autoimmunity Reviews, 17(4), 376-390
Type
Article
Article Type
Review
Keywords
Aquaporin-5 Water ChannelAutoimmune DisordersEhlers-Danlos-SyndromeEndoplasmic-Reticulum StressInduced Oxidative StressInflammationIntracellular CalciumIon ChannelsParotid Acinar-CellsPrimary Sjogrens-SyndromeRadiation-Induced XerostomiaRatSalivationSubmandibular-GlandsSystemic-Lupus-ErythematosusVersus-Host-DiseaseXerostomia
ISSN
1568-9972
Abstract
Xerostomia is a state of oral dryness associated with salivary gland dysfunction and is induced by stress, radiation and chemical therapy, various systemic and autoimmune diseases, and specific medications. Fluid secretion is interrupted by the stimulation of neurotransmitter-induced increase in cytosolic calcium ([Ca2+]i) in salivary gland acinar cells, prompting the mobilization of ion channels and their transporters. Salivary fluid and protein secretion are principally dependent on parasympathetic and sympathetic nerves. Various inflammatory cytokines allied with lymphocytic infiltration cause glandular damage and Sjogren's syndrome, an autoimmune exocrinopathy associated with hyposalivation. A defect in IP3Rs, a major calcium release channel, prompts inadequate agonist-induced [Ca2+]i in acinar cells and deters salivary flow. The store-operated calcium entry-mediated Ca2+ movement into the acini activates K+ and Cl- channels, which further opens a water channel protein, aquaporin-5, and triggers the release of fluid secretion from the salivary glands. The cellular mechanism of salivary gland dysfunction and hyposalivation has not yet been elucidated. In this review, we focused mainly on the proteins responsible for deficient saliva, the correlation between inflammation and salivation, autoimmune disorders and other ailments or complications associated with hyposalivation. © 2018 The Authors.
URI
http://hdl.handle.net/20.500.11750/5925
DOI
10.1016/j.autrev.2017.11.031
Publisher
Elsevier B.V.
Related Researcher
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Collection:
ETC1. Journal Articles


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