Title

Spatiotemporal Fluorescence-Based Biophysics from Single Particles to Single Cells

Alternative Title

단일 입자에서 단일 세포까지의 시공간적 형광 기반 생물물리학

DGIST Authors

Juhee Jang ; Byunghyuck Jung ; Daeha Seo

Advisor

정병혁

Co-Advisor(s)

Daeha Seo

Issued Date

2026

Awarded Date

2026-02-01

Type

Thesis

Description

Optical microscopy|Spatiotemporal fluorescence imaging|Single-entity quantification|Biointerface dynamics

Table Of Contents

0. Overview 1
1. Chapter Ⅰ. Precision Surface Engineering of small Extracellular Vesicles via a Modular Chimeric Adaptor Protein System 4
1.1 Abstract 4
1.2 Introduction 5
1.3 Results and Discussion 7
1.4 Conclusion 40
1.5 Experimental Detail 42
2. Chapter Ⅱ. Reconciling a Kinetic Model for Dimerization of the EGFR Using Single-Molecule Tracking in Living Cells 53
2.1 Abstract 53
2.2 Introduction 54
2.3 Results and Discussion 55
2.4 Conclusion 76
2.5 Experimental Detail 77
3. Chapter Ⅲ. Sublethal Mn²⁺ Exposure Perturbs Cellular Signaling Prior to Cytotoxicity 83
3.1 Abstract 83
3.2 Introduction 84
3.3 Results and Discussion 85
3.4 Conclusion 94
3.5 Experimental Detail 95
4. Reference 98

URI

https://scholar.dgist.ac.kr/handle/20.500.11750/59644
http://dgist.dcollection.net/common/orgView/200000948948

DOI

10.22677/THESIS.200000948948

Degree

Doctor

Department

Department of Physics and Chemistry

Publisher

DGIST

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