Detail View

  Department of Physics and Chemistry Theses Ph.D.

Rapid and Convenient Detection Strategies of Extracellular Vesicles for Clinical Applications

Citations

WEB OF SCIENCE

Citations

SCOPUS

Metadata Downloads

XML
Excel
DC Field Value Language
dc.contributor.advisor 홍선기 -
dc.contributor.author Subhra Sulipta Jena -
dc.date.accessioned 2026-09-01T19:30:46Z -
dc.date.available 2026-09-01T19:30:46Z -
dc.date.issued 2026 -
dc.identifier.uri https://scholar.dgist.ac.kr/handle/20.500.11750/60758 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200001006912 -
dc.description Extracellular vesicles, microRNA, Molecular beacons, Clinical diagnostics -
dc.description.tableofcontents List of Contents
Abstract i
List of contents ii
List of figures iv
List of Tables vii


I. INTRODUCTION 1
1.1 Background 2
1.1.1 Extracellular vesicles as biological messenger 2
1.1.2 Exosomal miRNAs as stable and informative biomarkers 2
1.1.3 Relevance of exosomal miRNAs in cardiovascular disease 2
1.1.4 Limitation of conventional exosomal miRNA detection 2
1.1.5 Direct in situ detection approaches for intact EVs 3
1.1.6 Fusion-based vesicle system for probe delivery 3
1.2 Motivation and Objective 3

II. EXPERIMENTAL SECTION 5

ⅠⅠⅠ. RESULTS AND DISCUSSION
3.1 Schematic representation of a vesicle fusion-based miRNA detection assay 10
3.2 Characterization of MB-encapsulated liposomes and fusion behavior in the SAFE
Assay 12
3.3 Comparison between conventional method with SAFE 13
3.4 Identification of cardiac injury-Related EV miRNAs 15
3.5 Verification of EV membrane Integrity after SAFE 17

3.6 Clinical validation of SAFE for diagnosing cardiovascular disease 19
3.7 Schematic representation of EV-based multiplex miRNA–protein detection 21
3.8 Relative Expression of CD63, CD24, and EpCAM in Five Colorectal Cancer
Cell Lines 23
3.9 Clinical Multiplex Analysis of Plasma EVs in Colorectal Cancer 24
3.10 Diagnostic evaluation of single and combined EV-associated biomarkers for
CRC discrimination. 26
3.11 Diagnostic performance analysis of single and combined EV-associated biomarkers
for CRC detection.28


IV. CONCLUSION 30

V. REFERENCES 31
요 약 문 34
Appendix A: List of Publication 35
Appendix B: List of Conferences 36		 -
dc.format.extent 37 -
dc.language eng -
dc.publisher DGIST -
dc.title Rapid and Convenient Detection Strategies of Extracellular Vesicles for Clinical Applications -
dc.title.alternative 임상 응용을 위한 세포외소포의 신속하고 간편한 검출 전략 -
dc.type Thesis -
dc.identifier.doi 10.22677/THESIS.200001006912 -
dc.description.degree Doctor -
dc.contributor.department Department of Physics and Chemistry -
dc.date.awarded 2026-08-01 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.MD J51 202608 -
dc.date.accepted 2026-07-21 -
dc.contributor.alternativeDepartment 화학물리학과 -
dc.subject.keyword Extracellular vesicles, microRNA, Molecular beacons, Clinical diagnostics -
dc.contributor.affiliatedAuthor Subhra Sulipta Jena -
dc.contributor.affiliatedAuthor Seonki Hong -
dc.contributor.alternativeName Jena Subhra Sulipta -
dc.contributor.alternativeName Seonki Hong -
dc.rights.embargoReleaseDate 2027-08-31 -
Show Simple Item Record

File Downloads

  • There are no files associated with this item.

공유

qrcode
공유하기

Total Views & Downloads

???jsp.display-item.statistics.view???: , ???jsp.display-item.statistics.download???: