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dc.contributor.author Ghazizadeh, Z. -
dc.contributor.author Fattahi, F. -
dc.contributor.author Mirzaei, M. -
dc.contributor.author Bayersaikhan, D. -
dc.contributor.author Lee, J. -
dc.contributor.author Chae, Se Hyun -
dc.contributor.author Hwang, Dae Hee -
dc.contributor.author Byun, K. -
dc.contributor.author Tabar, M.S. -
dc.contributor.author Taleahmad, S. -
dc.contributor.author Mirshahvaladi, S. -
dc.contributor.author Shabani, P. -
dc.contributor.author Fonoudi, H. -
dc.contributor.author Haynes, P.A. -
dc.contributor.author Baharvand, H. -
dc.contributor.author Aghdami, N. -
dc.contributor.author Evans, T. -
dc.contributor.author Lee, B. -
dc.contributor.author Salekdeh, G.H. -
dc.date.available 2018-04-11T03:46:35Z -
dc.date.created 2018-03-29 -
dc.date.issued 2018-03 -
dc.identifier.citation Stem Cell Reports, v.10, no.3, pp.848 - 859 -
dc.identifier.issn 2213-6711 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/6158 -
dc.description.abstract The LIM-homeodomain transcription factor ISL1 marks multipotent cardiac progenitors that give rise to cardiac muscle, endothelium, and smooth muscle cells. ISL1+ progenitors can be derived from human pluripotent stem cells, but the inability to efficiently isolate pure populations has limited their characterization. Using a genetic selection strategy, we were able to highly enrich ISL1+ cells derived from human embryonic stem cells. Comparative quantitative proteomic analysis of enriched ISL1+ cells identified ALCAM (CD166) as a surface marker that enabled the isolation of ISL1+ progenitor cells. ALCAM+/ISL1+ progenitors are multipotent and differentiate into cardiomyocytes, endothelial cells, and smooth muscle cells. Transplantation of ALCAM+ progenitors enhances tissue recovery, restores cardiac function, and improves angiogenesis through activation of AKT-MAPK signaling in a rat model of myocardial infarction, based on cardiac MRI and histology. Our study establishes an efficient method for scalable purification of human ISL1+ cardiac precursor cells for therapeutic applications. In this article, Salekdeh and colleagues show that ISL1+ cardiac progenitors can be purified from a heterogeneous population of hESC-derived cardiomyocytes using ALCAM. Transplantation of multipotent ISL1+/ALCAM+ progenitors enhances tissue recovery, restores cardiac function, and improves angiogenesis in a rat model of myocardial infarction, based on cardiac MRI and histology. © 2018 The Authors -
dc.language English -
dc.publisher Cell Press -
dc.title Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy -
dc.type Article -
dc.identifier.doi 10.1016/j.stemcr.2018.01.037 -
dc.identifier.wosid 000427349300015 -
dc.identifier.scopusid 2-s2.0-85042625075 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Stem Cell Reports -
dc.contributor.nonIdAuthor Ghazizadeh, Z. -
dc.contributor.nonIdAuthor Fattahi, F. -
dc.contributor.nonIdAuthor Mirzaei, M. -
dc.contributor.nonIdAuthor Bayersaikhan, D. -
dc.contributor.nonIdAuthor Lee, J. -
dc.contributor.nonIdAuthor Chae, Se Hyun -
dc.contributor.nonIdAuthor Byun, K. -
dc.contributor.nonIdAuthor Tabar, M.S. -
dc.contributor.nonIdAuthor Taleahmad, S. -
dc.contributor.nonIdAuthor Mirshahvaladi, S. -
dc.contributor.nonIdAuthor Shabani, P. -
dc.contributor.nonIdAuthor Fonoudi, H. -
dc.contributor.nonIdAuthor Haynes, P.A. -
dc.contributor.nonIdAuthor Baharvand, H. -
dc.contributor.nonIdAuthor Aghdami, N. -
dc.contributor.nonIdAuthor Evans, T. -
dc.contributor.nonIdAuthor Lee, B. -
dc.contributor.nonIdAuthor Salekdeh, G.H. -
dc.identifier.citationVolume 10 -
dc.identifier.citationNumber 3 -
dc.identifier.citationStartPage 848 -
dc.identifier.citationEndPage 859 -
dc.identifier.citationTitle Stem Cell Reports -
dc.type.journalArticle Article -
dc.description.isOpenAccess Y -
dc.subject.keywordPlus SPACEMAKER -
dc.subject.keywordPlus CARDIOVASCULAR PROGENITORS -
dc.subject.keywordPlus CELLS -
dc.subject.keywordPlus HEART -
dc.subject.keywordPlus CARDIOMYOCYTE -
dc.contributor.affiliatedAuthor Ghazizadeh, Z. -
dc.contributor.affiliatedAuthor Fattahi, F. -
dc.contributor.affiliatedAuthor Mirzaei, M. -
dc.contributor.affiliatedAuthor Bayersaikhan, D. -
dc.contributor.affiliatedAuthor Lee, J. -
dc.contributor.affiliatedAuthor Chae, Se Hyun -
dc.contributor.affiliatedAuthor Hwang, Dae Hee -
dc.contributor.affiliatedAuthor Byun, K. -
dc.contributor.affiliatedAuthor Tabar, M.S. -
dc.contributor.affiliatedAuthor Taleahmad, S. -
dc.contributor.affiliatedAuthor Mirshahvaladi, S. -
dc.contributor.affiliatedAuthor Shabani, P. -
dc.contributor.affiliatedAuthor Fonoudi, H. -
dc.contributor.affiliatedAuthor Haynes, P.A. -
dc.contributor.affiliatedAuthor Baharvand, H. -
dc.contributor.affiliatedAuthor Aghdami, N. -
dc.contributor.affiliatedAuthor Evans, T. -
dc.contributor.affiliatedAuthor Lee, B. -
dc.contributor.affiliatedAuthor Salekdeh, G.H. -
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Appears in Collections:
Department of New Biology Systems Biology and Medicine Lab 1. Journal Articles

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