Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Ghazizadeh, Z. | - |
dc.contributor.author | Fattahi, F. | - |
dc.contributor.author | Mirzaei, M. | - |
dc.contributor.author | Bayersaikhan, D. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Chae, Se Hyun | - |
dc.contributor.author | Hwang, Dae Hee | - |
dc.contributor.author | Byun, K. | - |
dc.contributor.author | Tabar, M.S. | - |
dc.contributor.author | Taleahmad, S. | - |
dc.contributor.author | Mirshahvaladi, S. | - |
dc.contributor.author | Shabani, P. | - |
dc.contributor.author | Fonoudi, H. | - |
dc.contributor.author | Haynes, P.A. | - |
dc.contributor.author | Baharvand, H. | - |
dc.contributor.author | Aghdami, N. | - |
dc.contributor.author | Evans, T. | - |
dc.contributor.author | Lee, B. | - |
dc.contributor.author | Salekdeh, G.H. | - |
dc.date.available | 2018-04-11T03:46:35Z | - |
dc.date.created | 2018-03-29 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | Stem Cell Reports, v.10, no.3, pp.848 - 859 | - |
dc.identifier.issn | 2213-6711 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/6158 | - |
dc.description.abstract | The LIM-homeodomain transcription factor ISL1 marks multipotent cardiac progenitors that give rise to cardiac muscle, endothelium, and smooth muscle cells. ISL1+ progenitors can be derived from human pluripotent stem cells, but the inability to efficiently isolate pure populations has limited their characterization. Using a genetic selection strategy, we were able to highly enrich ISL1+ cells derived from human embryonic stem cells. Comparative quantitative proteomic analysis of enriched ISL1+ cells identified ALCAM (CD166) as a surface marker that enabled the isolation of ISL1+ progenitor cells. ALCAM+/ISL1+ progenitors are multipotent and differentiate into cardiomyocytes, endothelial cells, and smooth muscle cells. Transplantation of ALCAM+ progenitors enhances tissue recovery, restores cardiac function, and improves angiogenesis through activation of AKT-MAPK signaling in a rat model of myocardial infarction, based on cardiac MRI and histology. Our study establishes an efficient method for scalable purification of human ISL1+ cardiac precursor cells for therapeutic applications. In this article, Salekdeh and colleagues show that ISL1+ cardiac progenitors can be purified from a heterogeneous population of hESC-derived cardiomyocytes using ALCAM. Transplantation of multipotent ISL1+/ALCAM+ progenitors enhances tissue recovery, restores cardiac function, and improves angiogenesis in a rat model of myocardial infarction, based on cardiac MRI and histology. © 2018 The Authors | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.title | Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.stemcr.2018.01.037 | - |
dc.identifier.wosid | 000427349300015 | - |
dc.identifier.scopusid | 2-s2.0-85042625075 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Stem Cell Reports | - |
dc.contributor.nonIdAuthor | Ghazizadeh, Z. | - |
dc.contributor.nonIdAuthor | Fattahi, F. | - |
dc.contributor.nonIdAuthor | Mirzaei, M. | - |
dc.contributor.nonIdAuthor | Bayersaikhan, D. | - |
dc.contributor.nonIdAuthor | Lee, J. | - |
dc.contributor.nonIdAuthor | Chae, Se Hyun | - |
dc.contributor.nonIdAuthor | Byun, K. | - |
dc.contributor.nonIdAuthor | Tabar, M.S. | - |
dc.contributor.nonIdAuthor | Taleahmad, S. | - |
dc.contributor.nonIdAuthor | Mirshahvaladi, S. | - |
dc.contributor.nonIdAuthor | Shabani, P. | - |
dc.contributor.nonIdAuthor | Fonoudi, H. | - |
dc.contributor.nonIdAuthor | Haynes, P.A. | - |
dc.contributor.nonIdAuthor | Baharvand, H. | - |
dc.contributor.nonIdAuthor | Aghdami, N. | - |
dc.contributor.nonIdAuthor | Evans, T. | - |
dc.contributor.nonIdAuthor | Lee, B. | - |
dc.contributor.nonIdAuthor | Salekdeh, G.H. | - |
dc.identifier.citationVolume | 10 | - |
dc.identifier.citationNumber | 3 | - |
dc.identifier.citationStartPage | 848 | - |
dc.identifier.citationEndPage | 859 | - |
dc.identifier.citationTitle | Stem Cell Reports | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | SPACEMAKER | - |
dc.subject.keywordPlus | CARDIOVASCULAR PROGENITORS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | CARDIOMYOCYTE | - |
dc.contributor.affiliatedAuthor | Ghazizadeh, Z. | - |
dc.contributor.affiliatedAuthor | Fattahi, F. | - |
dc.contributor.affiliatedAuthor | Mirzaei, M. | - |
dc.contributor.affiliatedAuthor | Bayersaikhan, D. | - |
dc.contributor.affiliatedAuthor | Lee, J. | - |
dc.contributor.affiliatedAuthor | Chae, Se Hyun | - |
dc.contributor.affiliatedAuthor | Hwang, Dae Hee | - |
dc.contributor.affiliatedAuthor | Byun, K. | - |
dc.contributor.affiliatedAuthor | Tabar, M.S. | - |
dc.contributor.affiliatedAuthor | Taleahmad, S. | - |
dc.contributor.affiliatedAuthor | Mirshahvaladi, S. | - |
dc.contributor.affiliatedAuthor | Shabani, P. | - |
dc.contributor.affiliatedAuthor | Fonoudi, H. | - |
dc.contributor.affiliatedAuthor | Haynes, P.A. | - |
dc.contributor.affiliatedAuthor | Baharvand, H. | - |
dc.contributor.affiliatedAuthor | Aghdami, N. | - |
dc.contributor.affiliatedAuthor | Evans, T. | - |
dc.contributor.affiliatedAuthor | Lee, B. | - |
dc.contributor.affiliatedAuthor | Salekdeh, G.H. | - |