Cited 23 time in webofscience Cited 23 time in scopus

Exosomes as diagnostic biomarkers in cancer

Title
Exosomes as diagnostic biomarkers in cancer
Authors
Kim, Jung-HeeKim, Eun JooLee, Mi Young
DGIST Authors
Kim, Jung-Hee; Kim, Eun Joo
Issue Date
2018-04
Citation
Molecular and Cellular Toxicology, 14(2), 113-122
Type
Article
Article Type
Review
Author Keywords
ExosomeBiomarkermiRNAProteinCancer
Keywords
CIRCULATING EXTRACELLULAR VESICLESTUMOR-DERIVED EXOSOMESRENAL-CELL CARCINOMAOVARIAN-CANCERBREAST-CANCERLUNG-CANCERPROSTATE-CANCERPANCREATIC-CANCERNASOPHARYNGEAL CARCINOMACOLORECTAL-CANCER
ISSN
1738-642X
Abstract
Purpose of review: Exosomes are extracellular vesicles of 30-150 nm diameter, secreted from nearly all mammalian cells through fusion of multivesicular bodies with the plasma membrane. Owing to the differences in the properties of exosomes and microvesicles released through outward budding of the plasma membrane, exosomes have recently received increasing interest. This review discusses the current status of exosome research for diagnostic biomarkers in cancers. The scope of information that can be acquired from exosomal contents potentially include tumour progression, detection of metastasis, and possible chemotherapeutic resistance, which can facilitate clinical decisions in precision medicine. Recent findings: Exosomes protect molecular components including miRNAs and proteins from enzymatic degradation during circulation and serve as stable cargo for them. miRNAs transferred by exosomes have emerged as novel regulators of cellular function in various types of cancers. In addition, exosomes contain numerous plasma membrane and cytosolic proteins and exosome- specific proteins. However, many of the experiments are limited in their methods for the isolation and purification of exosomes. Nevertheless, the physiological and pathological significance of the role of exosomes in miRNA- or protein-based cell-to-cell or tissue-to-tissue communication has been highlighted. © 2018, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media B.V., part of Springer Nature.
URI
http://hdl.handle.net/20.500.11750/6208
DOI
10.1007/s13273-018-0014-4
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
Related Researcher
  • Author Kim, Eunjoo  
  • Research Interests Biomarker, liquid biopsy, molecular diagnosis, nanobiosensor, drug delivery, exosome
Files:
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Collection:
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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