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Ixeris dentata extract increases salivary secretion through the regulation of endoplasmic reticulum stress in a diabetes-induced xerostomia rat model

Title
Ixeris dentata extract increases salivary secretion through the regulation of endoplasmic reticulum stress in a diabetes-induced xerostomia rat model
Authors
Bhattarai, Kashi RaLee, Hwa YoungKim, Seung HyunKim, Hyung RyongChae, Han Jung
DGIST Authors
Kim, Hyung Ryong
Issue Date
2018-04
Citation
International Journal of Molecular Sciences, 19(4)
Type
Article
Article Type
Article
Author Keywords
AmylaseAquaporin 5Diabetes-associated xerostomiaEndoplasmic reticulum stressIxeris dentataSaliva secretion
ISSN
1661-6596
Abstract
This study aimed to investigate the molecular mechanism of diabetes mellitus (DM)-induced dry mouth and an application of natural products from Ixeris dentata (IXD), a recently suggested regulator of amylase secretion in salivary cells. Vehicle-treated or diabetic rats were orally treated with either water or an IXD extract for 10 days to observe the effect on salivary flow. We found that the IXD extract increased aquaporin 5 (AQP5) and alpha-amylase protein expression in the submandibular gland along with salivary flow rate. Similarly, the IXD extract and its purified compound increased amylase secretion in high glucose-exposed human salivary gland cells. Furthermore, increased endoplasmic reticulum stress response in the submandibular gland of diabetic rats was inhibited by treatment with the IXD extract, suggesting that IXD extract treatment improves the ER environment by increasing the protein folding capacity. Thus, pharmacological treatment with the IXD extract is suggested to relieve DM-induced dry mouth symptoms. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/6251
DOI
10.3390/ijms19041059
Publisher
MDPI AG
Files:
Collection:
ETC1. Journal Articles


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