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Solenoid Driven Pressure Valve System: Toward Versatile Fluidic Control in Paper Microfluidics

Title
Solenoid Driven Pressure Valve System: Toward Versatile Fluidic Control in Paper Microfluidics
Authors
Kim, Taehoon H.Hahn, Young KiLee, Jungminvan Noort, DannyKim, Minseok S.
DGIST Authors
Kim, Minseok S.
Issue Date
2018-02
Citation
Analytical Chemistry, 90(4), 2534-2541
Type
Article
Article Type
Article
Keywords
2-DIMENSIONAL PAPERDEVICESDIAGNOSTICSNETWORKSBARRIERSSENSORSASSAYSELISATIMEFLOW
ISSN
0003-2700
Abstract
As paper-based diagnostics has become predominantly driven by more advanced microfluidic technology, many of the research efforts are still focused on developing reliable and versatile fluidic control devices, apart from improving sensitivity and reproducibility. In this work, we introduce a novel and robust paper fluidic control system enabling versatile fluidic control. The system comprises a linear push-pull solenoid and an Arduino Uno microcontroller. The precisely controlled pressure exerted on the paper stops the flow. We first determined the stroke distance of the solenoid to obtain a constant pressure while examining the fluidic time delay as a function of the pressure. Results showed that strips of grade 1 chromatography paper had superior reproducibility in fluid transport. Next, we characterized the reproducibility of the fluidic velocity which depends on the type and grade of paper used. As such, we were able to control the flow velocity on the paper and also achieve a complete stop of flow with a pressure over 2.0 MPa. Notably, after the actuation of the pressure driven valve (PDV), the previously pressed area regained its original flow properties. This means that, even on a previously pressed area, multiple valve operations can be successfully conducted. To the best of our knowledge, this is the first demonstration of an active and repetitive valve operation in paper microfluidics. As a proof of concept, we have chosen to perform a multistep detection system in the form of an enzyme-linked immunosorbent assay with mouse IgG as the target analyte. © 2018 American Chemical Society.
URI
http://hdl.handle.net/20.500.11750/8989
DOI
10.1021/acs.analchem.7b03791
Publisher
American Chemical Society
Related Researcher
Files:
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Collection:
Department of New BiologyBioDr. Lab - Nanobiomedicine1. Journal Articles


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