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Progressive fuzzy cation- assembly of biological catecholamines
- Progressive fuzzy cation- assembly of biological catecholamines
- Hong, Seonki; Wang, Younseon; Park, Sung Young; Lee, Haeshin
- DGIST Authors
- Hong, Seonki
- Issue Date
- Science Advances, 4(9), 1-10
- Article Type
- Amines; Biological systems; Energy efficiency; Lipid bilayers; Positive ions; Proteins; Reaction intermediates; Biological functions; Cellular function; Energy-efficient process; Hierarchical assemblies; Intermolecular assembly; Oxidation pathway; Primary mechanism; Wettability control; Assembly
- Biological functions depend on biomolecular assembly processes. Assemblies of lipid bilayers, actins, microtubules, or chromosomes are indispensable for cellular functions. These hierarchical assembly processes are reasonably predictable by understanding chemical structures of the defined building blocks and their interactions. However, biopigment assembly is rather fuzzy and unpredictable because a series of covalently coupled intermediates from catecholamine oxidation pathways progressively form a higher-level hierarchy. This study reports a different yet unexplored type of assembly process named “cation- progressive assembly.” We demonstrated for the first time that the cation- is the primary mechanism for intermolecular assembly in dopamine-melanin biopigment. We also found that the self-assembled products physically grow and chemically gain new functions “progressively” over time in which cation- plays important roles. The progressive assembly explains how biological systems produce wide spectra of pigment colors and broad wavelength absorption through energy-efficient processes. Furthermore, we also demonstrate surface-independent wettability control using cation- progressive assembly. Copyright © 2018 The Authors, some rights reserved;.
- American Association for the Advancement of Science
- Related Researcher
Biomaterials & Biointerface Engineering Laboratory
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- Department of Emerging Materials ScienceBiomaterials & Biointerface Engineering Laboratory1. Journal Articles
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