Cited 12 time in webofscience Cited 14 time in scopus

Progressive fuzzy cation- assembly of biological catecholamines

Title
Progressive fuzzy cation- assembly of biological catecholamines
Authors
Hong, SeonkiWang, YounseonPark, Sung YoungLee, Haeshin
DGIST Authors
Hong, Seonki
Issue Date
2018-09
Citation
Science Advances, 4(9), 1-10
Type
Article
Article Type
Article
Keywords
AminesBiological systemsEnergy efficiencyLipid bilayersPositive ionsProteinsReaction intermediatesBiological functionsCellular functionEnergy-efficient processHierarchical assembliesIntermolecular assemblyOxidation pathwayPrimary mechanismWettability controlAssembly
ISSN
2375-2548
Abstract
Biological functions depend on biomolecular assembly processes. Assemblies of lipid bilayers, actins, microtubules, or chromosomes are indispensable for cellular functions. These hierarchical assembly processes are reasonably predictable by understanding chemical structures of the defined building blocks and their interactions. However, biopigment assembly is rather fuzzy and unpredictable because a series of covalently coupled intermediates from catecholamine oxidation pathways progressively form a higher-level hierarchy. This study reports a different yet unexplored type of assembly process named “cation- progressive assembly.” We demonstrated for the first time that the cation- is the primary mechanism for intermolecular assembly in dopamine-melanin biopigment. We also found that the self-assembled products physically grow and chemically gain new functions “progressively” over time in which cation- plays important roles. The progressive assembly explains how biological systems produce wide spectra of pigment colors and broad wavelength absorption through energy-efficient processes. Furthermore, we also demonstrate surface-independent wettability control using cation- progressive assembly. Copyright © 2018 The Authors, some rights reserved;.
URI
http://hdl.handle.net/20.500.11750/9339
DOI
10.1126/sciadv.aat7457
Publisher
American Association for the Advancement of Science
Related Researcher
  • Author Hong, Seonki Biomaterials & Biointerface Engineering Laboratory
  • Research Interests
Files:
There are no files associated with this item.
Collection:
Department of Emerging Materials ScienceBiomaterials & Biointerface Engineering Laboratory1. Journal Articles


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