Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Bo-Ram | - |
dc.contributor.author | Kim, Jung-Hee | - |
dc.contributor.author | Choi, Eun-Sook | - |
dc.contributor.author | Cho, Jung-Hoon | - |
dc.contributor.author | Kim, Eunjoo | - |
dc.date.accessioned | 2018-10-11T02:03:06Z | - |
dc.date.available | 2018-10-11T02:03:06Z | - |
dc.date.created | 2018-09-28 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.citation | International Journal of Nanomedicine, v.13, pp.5335 - 5345 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/9348 | - |
dc.description.abstract | Introduction: Exosomes, nano-sized extracellular vesicles, are known to circulate through the blood stream to transfer molecular signals from tissue to tissue. Methods: To determine whether exosomes affect aging in animals, we primarily identified the changes in exosomal miRNA contents during the aging process. In exosomes from 12-month-old mice, mmu-miR-126-5p and mmu-miR-466c-5p levels were decreased and mmu-miR-184-3p and mmu-miR-200b-5p levels were increased significantly compared with those of 3-month-old mice. Their levels in exosomes were partially correlated with those in tissues: levels of only mmu-miR-126-5p and mmu-miR-466c-5p in lungs and/or liver were decreased, but those of mmu-miR-184-3p and mmu-miR-200b-5p in tissues did not coincide with those of exosomes. Results and discussion: In the aged tissues injected with young exosomes isolated from serum, mmu-miR-126b-5p levels were reversed in the lungs and liver. Expression changes in aging-associated molecules in young exosome-injected mice were obvious: p16(Ink4A), MTOR, and IGF1R were significantly downregulated in the lungs and/or liver of old mice. In addition, telomerase-related genes such as Men1, Mre11a, Tep1, Terf2, Tert, and Tnks were significantly upregulated in the liver of old mice after injection of young exosomes. Conclusion: These results indicate that exosomes from young mice could reverse the expression pattern of aging-associated molecules in aged mice. Eventually, exosomes may be used as a novel approach for the treatment and diagnosis of aging animals. | - |
dc.language | English | - |
dc.publisher | Dove Medical Press Ltd | - |
dc.title | Effect of young exosomes injected in aged mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.2147/IJN.S170680 | - |
dc.identifier.wosid | 000444284400001 | - |
dc.identifier.scopusid | 2-s2.0-85055665118 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | International Journal of Nanomedicine | - |
dc.contributor.nonIdAuthor | Choi, Eun-Sook | - |
dc.contributor.nonIdAuthor | Cho, Jung-Hoon | - |
dc.identifier.citationVolume | 13 | - |
dc.identifier.citationStartPage | 5335 | - |
dc.identifier.citationEndPage | 5345 | - |
dc.identifier.citationTitle | International Journal of Nanomedicine | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | exosome | - |
dc.subject.keywordAuthor | injection | - |
dc.subject.keywordAuthor | reverse aging | - |
dc.subject.keywordAuthor | telomerase | - |
dc.subject.keywordAuthor | biomarker | - |
dc.subject.keywordAuthor | molecular therapy | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MIRNA | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | TELOMERASE | - |
dc.subject.keywordPlus | SENESCENCE | - |
dc.subject.keywordPlus | MICRORNAS | - |
dc.contributor.affiliatedAuthor | Lee, Bo-Ram | - |
dc.contributor.affiliatedAuthor | Kim, Jung-Hee | - |
dc.contributor.affiliatedAuthor | Choi, Eun-Sook | - |
dc.contributor.affiliatedAuthor | Cho, Jung-Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Eunjoo | - |