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dc.contributor.author Chae, Sehyun -
dc.contributor.author Kim, Su-Jin -
dc.contributor.author Koo, Young Do -
dc.contributor.author Lee, Jung Hwa -
dc.contributor.author Kim, Hokeun -
dc.contributor.author Ahn, Byung Yong -
dc.contributor.author Ha, Yong-Chan -
dc.contributor.author Kim, Yong-Hak -
dc.contributor.author Jang, Mi Gyeong -
dc.contributor.author Koo, Kyung-Hoi -
dc.contributor.author Choi, Sung Hee -
dc.contributor.author Lim, Soo -
dc.contributor.author Park, Young Joo -
dc.contributor.author Jang, Hak Chul -
dc.contributor.author Hwang, Daehee -
dc.contributor.author Lee, Sang-Won -
dc.contributor.author Park, Kyong Soo -
dc.date.accessioned 2018-10-30T05:59:53Z -
dc.date.available 2018-10-30T05:59:53Z -
dc.date.created 2018-10-15 -
dc.date.issued 2018-09 -
dc.identifier.issn 1226-3613 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/9388 -
dc.description.abstract The pathogenesis of type 2 diabetes mellitus (T2DM) is closely associated with mitochondrial functions in insulin-responsive tissues. The mitochondrial proteome, compared with the mitochondrial genome, which only contains 37 genes in humans, can provide more comprehensive information for thousands of mitochondrial proteins regarding T2DM-associated mitochondrial functions. However, T2DM-associated protein signatures in insulin-responsive tissues are still unclear. Here, we performed extensive proteome profiling of mitochondria from skeletal muscles in nine T2DM patients and nine nondiabetic controls. A comparison of the mitochondrial proteomes identified 335 differentially expressed proteins (DEPs) between T2DM and nondiabetic samples. Functional and network analyses of the DEPs showed that mitochondrial metabolic processes were downregulated and mitochondria-associated ER membrane (MAM) processes were upregulated. Of the DEPs, we selected two (NDUFS3 and COX2) for downregulated oxidative phosphorylation and three (CALR, SORT, and RAB1A) for upregulated calcium and protein transport as representative mitochondrial and MAM processes, respectively, and then confirmed their differential expression in independent mouse and human samples. Therefore, we propose that these five proteins be used as a potential protein profile that is indicative of the dysregulation of mitochondrial functions in T2DM, representing downregulated oxidative phosphorylation and upregulated MAM functions. -
dc.language English -
dc.publisher 생화학분자생물학회 -
dc.title A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles -
dc.type Article -
dc.identifier.doi 10.1038/s12276-018-0154-6 -
dc.identifier.scopusid 2-s2.0-85055206571 -
dc.identifier.bibliographicCitation Experimental and Molecular Medicine, v.50, no.9, pp.1 - 14 -
dc.identifier.kciid ART002389378 -
dc.description.isOpenAccess TRUE -
dc.subject.keywordPlus MASS-SPECTROMETRIC DATA -
dc.subject.keywordPlus HEPATIC SORTILIN 1 -
dc.subject.keywordPlus INSULIN-RESISTANCE -
dc.subject.keywordPlus SOFTWARE TOOL -
dc.subject.keywordPlus BETA-CELLS -
dc.subject.keywordPlus DYSFUNCTION -
dc.subject.keywordPlus DATABASE -
dc.subject.keywordPlus DISEASE -
dc.subject.keywordPlus IDENTIFICATION -
dc.subject.keywordPlus PROTEINS -
dc.citation.endPage 14 -
dc.citation.number 9 -
dc.citation.startPage 1 -
dc.citation.title Experimental and Molecular Medicine -
dc.citation.volume 50 -
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Department of New Biology Systems Biology and Medicine Lab 1. Journal Articles

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