Cited 8 time in webofscience Cited 7 time in scopus

Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans

Title
Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans
Authors
Son, Heehwa G.Seo, KeunheeSeo, MihwaPark, SangsoonHam, SeokjinAn, Seon Woo A.Choi, Eun-SeokLee, YujinBaek, HaeshimKim, EunjuRyu, YoungjaeHa, Chang ManHsu, Ao-LinRoh, Tae-YoungJang, Sung KeyLee, Seung-Jae V.
Issue Date
2018-12
Citation
Genes and Development, 32(23-24), 1562-1575
Type
Article
Article Type
Article
ISSN
0890-9369
Abstract
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS. © 2018 Son et al.
URI
http://hdl.handle.net/20.500.11750/9503
DOI
10.1101/gad.317362.118
Publisher
Cold Spring Harbor Laboratory Press
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