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Potential application of ixeris dentata in the prevention and treatment of aging-induced dry mouth

Title
Potential application of ixeris dentata in the prevention and treatment of aging-induced dry mouth
Authors
Bhattarai, Kashi RajLee, Hwa-YoungKim, Seung-HyunPark, Jong-SugKim, Hyung-RyongChae, Han-Jung
DGIST Authors
Kim, Hyung-Ryong
Issue Date
2018-12
Citation
Nutrients, 10(12)
Type
Article
Article Type
Article
ISSN
2072-6643
Abstract
Dry mouth is a common complaint among the elderly population. The aim of this study was to investigate the effect of Ixeris dentata (IXD) extract on aging-induced dry mouth. We used young (two months) and aged (20 months) SD rats in our study. Using water as the vehicle, IXD extract (25, 50, and 100 mg/kg) was given via oral gavage to the young and aged rats for eight weeks. We found that the salivary flow rate relative to the submandibular gland weight was differently influenced by IXD extract treatment. IXD extract augmented the submandibular gland acinar cells, which are depleted during aging. In addition, the decreased salivary alpha-amylase, inositol triphosphate receptor, and aquaporin-5 in the aging rats were upregulated by IXD treatment. Free radical-induced oxidative stress in the aging rats was also alleviated in the IXD-treated group. The formation of high molecular weight complexes of protein disulfide isomerase, decreased expression of an ER chaperone (GRP78), and increased ER stress response (ATF-4, CHOP and p-JNK) in aging rats was regulated with IXD treatment, and eventually increased salivary secretions from the aging submandibular glands. These are the first data to suggest that IXD extract might ameliorate aging-associated oral dryness by regulating the ER environment. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/9543
DOI
10.3390/nu10121989
Publisher
MDPI AG
Files:
Collection:
ETC1. Journal Articles


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