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Isolation of amylase regulators from the leaves of Ixeridium dentatum

Title
Isolation of amylase regulators from the leaves of Ixeridium dentatum
Authors
Park, SeonJuNguyen Xuan NhiemPark, Jun HyungBhattarai, Kashi RajChae, Han-JungKim, Hyung-RyongKim, Seung Hyun
DGIST Authors
Kim, Hyung-Ryong
Issue Date
ACCEPT
Citation
Natural Product Research
Type
Article
Article Type
Article; Early Access
Author Keyword
Ixeridium dentatum; sesquiterpene lactone; phenylethanoid; amylase secretion activity
Keyword
SESQUITERPENE LACTONES; ORAL-HEALTH; CONSTITUENTS; GLYCOSIDES
ISSN
1478-6419
Abstract
Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3–13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1–2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
URI
http://hdl.handle.net/20.500.11750/9819
DOI
10.1080/14786419.2019.1599885
Publisher
Taylor & Francis
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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