이재민
Lee, Jaemin학력
- 2003 ~ 2008미시간대 박사
- 1999 ~ 2001서울대학교 석사
- 1992 ~ 1996서울대학교 학사
경력
- 2010 ~ 2016하버드대학 / 연구원
- 2009 ~ 2009미시간대학 / 연구원
- 2002 ~ 2003Albert Einstein College of Medicine, USA / Research Assistant
수상실적
연구실 소개
- Aging, Metabolism and Physiology Lab
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Cells under ER stress employ signaling events called the “unfolded protein response” (UPR) to restore ER homeostasis. Among signaling molecules in UPR, X-box binding protein 1 (XBP1s) is one of key signaling molecules and has been shown to play a crucial role in the hypothalamus, liver and pancreatic β cells’ metabolic regulation. There is “cross-talk” between XBP1s and other signaling molecules including p38 MAPK, IKKβ, Brd7, PI3K and FoxO1. Furthermore, XBP1s interactome is critically involved in metabolic homeostasis. These findings clearly demonstrate that ER stress and its related signaling pathways are critically important in metabolic regulation.Our research interests stem from the existence of various interactions surrounding UPR and their critical involvement in metabolic homeostasis, and their subsequent potentials as therapeutics toward obesity, type 2 diabetes and other metabolic disorders. We identify novel interactions between UPR and other signaling pathways and investigate their roles in metabolic homeostasis.
Research Interests
Related Keyword
- "Engineered extracellular vesicles with surface FGF21 and enclosed miR-223 for treating metabolic dysfunction-associated steatohepatitis", Cho, Hanchae. (2025-10). Engineered extracellular vesicles with surface FGF21 and enclosed miR-223 for treating metabolic dysfunction-associated steatohepatitis. Biomaterials, 321. doi: 10.1016/j.biomaterials.2025.123321
- "Exploring Renal Pyruvate Metabolism as a Therapeutic Avenue for Diabetic Kidney Injury", Diabetes & Metabolism Journal, v.48, no.3, pp.385 - 386
- "Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis", Jung, Su-Ryun. (2024-01). Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis. Korean Journal of Physiology & Pharmacology, 28(1), 31–38. doi: 10.4196/kjpp.2024.28.1.31
- "ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets", Gao, Yurong. (2024-01). ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets. Molecules and Cells, 47(1), 1–11. doi: 10.1016/j.mocell.2023.12.002
- "Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression", Lee, Ji-Hye. (2023-11). Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression. American Journal of Physiology - Endocrinology and Metabolism, 325(5), E448–E465. doi: 10.1152/ajpendo.00156.2023
연구 뉴스
- 대사성 난치질환 MASH 치료 위한 차세대 엑소좀 기반 복합 치료 기술 개발 2025-04-16
연구분야
미래유망 신기술(6T)
국가과학기술표준분류