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Multifarious Transit Gates for Programmable Delivery of Bio-functionalized Matters

Title
Multifarious Transit Gates for Programmable Delivery of Bio-functionalized Matters
Authors
Hu, XinghaoTorati, Sri RamuluKim, HyeonseolYoon, JonghwanLim, ByeonghwaKim, KunwooSitti, MetinKim, CheolGi
DGIST Authors
Kim, CheolGi
Issue Date
ACCEPT
Citation
Small
Type
Article
Article Type
Article
Author Keyword
biofunctionalization; micromagnets; microrobotic particles; on-chip arrays; programmable gating
Keyword
Medical applications; Biofunctionalization; Biomedical applications; Digital manipulation; Fabrication process; Micromagnets; On chips; programmable gating; Pulsed magnetic fields; Biomolecules
ISSN
1613-6810
Abstract
Programmable delivery of biological matter is indispensable for the massive arrays of individual objects in biochemical and biomedical applications. Although a digital manipulation of single cells has been implemented by the integrated circuits of micromagnetophoretic patterns with current wires, the complex fabrication process and multiple current operation steps restrict its practical application for biomolecule arrays. Here, a convenient approach using multifarious transit gates is proposed, for digital manipulation of biofunctionalized microrobotic particles that can pass through the local energy barriers by a time-dependent pulsed magnetic field instead of multiple current wires. The multifarious transit gates including return, delay, and resistance linear gates, as well as dividing, reversed, and rectifying T-junction gates, are investigated theoretically and experimentally for the programmable manipulation of microrobotic particles. The results demonstrate that, a suitable angle of the gating field at a suitable time zone is crucial to implement digital operations at integrated multifarious transit gates along bifurcation paths to trap microrobotic particles in specific apartments, paving the way for flexible on-chip arrays of biomolecules and cells. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
http://hdl.handle.net/20.500.11750/10048
DOI
10.1002/smll.201901105
Publisher
Wiley-VCH Verlag
Related Researcher
  • Author Kim, CheolGi Lab for NanoBio-MatErials & SpinTronics(nBEST)
  • Research Interests Magnetic Materials and Spintronics; Converging Technology of Nanomaterials and Biomaterials; Bio-NEMS;MEMS
Files:
There are no files associated with this item.
Collection:
Department of Emerging Materials ScienceLab for NanoBio-Materials & SpinTronics(nBEST)1. Journal Articles


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