Cited 0 time in
Cited 0 time in
Refining a Pathogen's Genome to Know the Enemy Better for the Winning Battles
- Refining a Pathogen's Genome to Know the Enemy Better for the Winning Battles
- Mohammad, Hazara Begum; Lee, Seung-Eun; Kim, Min-Sik
- DGIST Authors
- Kim, Min-Sik
- Issue Date
- Proteomics, 19(9), 1900005
- Article Type
- Editorial Material; Note
- Author Keywords
- genome annotation; novel gene discovery; pathogenicity; proteogenomics
- gene amplification; infectious agent; mass spectrometry; nonhuman; note; pathogenicity; polymerase chain reaction; proteogenomics; reverse transcription
- Clavibacter michiganensis, subsp. michiganens is a gram positive bacterial pathogen infecting tomato, resulting in the great losses of yield and quality worldwide. Despite its great impact on economics, we do not fully understand the virulence factors from its genome probably due to imperfect genome annotation. Peritore-Galve et al. utilized proteogenomic approach to identify 26 novel protein-coding regions, to extend 59 annotated open reading frames and to confirm protein expression for ≈70% of predicted gene models of Clavibacter michiganensis subsp. michiganensis. New findings by the proteogenomics technique were further confirmed using reverse transcription-polymerase chain reaction. To win battles with pathogens, it is advantageous to know about our enemies accurately which can be achieved by mass spectrometry-based identifications of novel protein-coding regions in genomes. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- John Wiley & Sons Ltd.
- Related Researcher
Laboratory for QBIO and Precision Medicine
Cancer Proteogenomics, Biomarker Discovery, Integrative Multi-Omics
There are no files associated with this item.
- Department of New BiologyLaboratory for QBIO and Precision Medicine1. Journal Articles
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.