Cited 0 time in webofscience Cited 0 time in scopus

Artificial Control of Cell Signaling Using a Photocleavable Cobalt(III)–Nitrosyl Complex

Title
Artificial Control of Cell Signaling Using a Photocleavable Cobalt(III)–Nitrosyl Complex
Authors
Shin, SangwonChoe, JisuPark, YoungchanJeong, DonghyunSong, HyunjoonYou, YoungminSeo, DaehaCho, Jaeheung
DGIST Authors
Seo, DaehaCho, Jaeheung
Issue Date
2019-07
Citation
Angewandte Chemie - International Edition, 58(30), 10126-10131
Type
Article
Article Type
Article
Author Keywords
cobalt(III)-nitrosyl complexkinase translocation reporternitric oxidephotolysissignal transduction
Keywords
NITRIC-OXIDES-NITROSYLATIONLIPID RAFTSREACTIVITYNOMECHANISMACTIVATIONCHEMISTRYREDUCTASERELEVANT
ISSN
1433-7851
Abstract
Cells use gaseous molecules such as nitric oxide (NO) to transmit both intracellular and intercellular signals. In principle, the endogenous small molecules regulate physiological changes, but it is unclear how randomly diffusive molecules trigger and discriminate signaling programs. Herein, it is shown that gasotransmitters use time-dependent dynamics to discriminate the endogenous and exogenous inputs. For a real-time stimulation of cell signaling, we synthesized a photo-cleavable metal–nitrosyl complex, [CoIII(MDAP)(NO)(CH3CN)]2+ (MDAP=N,N′-dimethyl-2,11-diaza[3,3](2,6)pyridinophane), which can stably deliver and selectively release NO with fine temporal resolution in the cytosol, and used this to study the extracellular signal-regulated kinases (ERKs), revealing how cells use both exogenous and endogenous NO to disentangle cellular responses. This technique can be to understand how diverse cellular signaling networks are dynamically interconnected and also to control drug delivery systems. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
http://hdl.handle.net/20.500.11750/10104
DOI
10.1002/anie.201903106
Publisher
Wiley-VCH Verlag
Related Researcher
  • Author Cho, Jaeheung Biomimetic Materials Laboratory
  • Research Interests Biomimetics; Metalloenzymes; Nitric Oxide Suppliers in Brain; Biomimetic Materials in Life
Files:
There are no files associated with this item.
Collection:
Department of Emerging Materials ScienceBiomimetic Materials Laboratory1. Journal Articles
Department of Emerging Materials ScienceSMALL LAB(Single Molecule Approaches to ceLL Lab)1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE