Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 이성배 | - |
| dc.contributor.author | Eun Seon Kim | - |
| dc.date.accessioned | 2019-08-22T16:00:07Z | - |
| dc.date.available | 2019-08-22T16:00:07Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000218831 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/10448 | - |
| dc.description | ALS/FTD, C9ORF72, DPR, Staufen, Drosophila, 루게릭 병, 전두측두엽 치매, 초파리 | - |
| dc.description.statementofresponsibility | prohibition | - |
| dc.description.tableofcontents | Abstract i List of contents ii List of figures iii I. INTRODUCTION 1 1.1 C9ORF72 expansion causes ALS/FTD pathology 1 1.2 Arginine-rich DPR proteins mainly contribute to C9ALS/FTD pathology 2 1.3 Pathogenic role of Staufen remains elusive in C9ALS/FTD pathology 3 II. MATERIALS AND METHODS 5 III. RESULTS 15 3.1 Arginine-rich DPR proteins increase nuclear accumulation of Staufen 15 3.2 Increased accumulation of nuclear Staufen partially co-localizes with heterochromatin 28 3.3 Increased nuclear accumulation of Staufen is mRNA dependent 34 3.4 Loss of Staufen rescues poly(PR)-mediated toxicity 43 IV. DISCUSSION 47 V. REFERENCES 49 VI. SUMMARY (국문요약) 53 |
- |
| dc.format.extent | 55 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.source | /home/dspace/dspace53/upload/200000218831.pdf | - |
| dc.title | Increased accumulation of Staufen in nucleus contributes to C9ALS/FTD pathology | - |
| dc.title.alternative | 핵 속에 축적된 Staufen 단백질이 C9ALS/FTD 병리 기전에 기여 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/thesis.200000218831 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Department of Brain and Cognitive Sciences | - |
| dc.contributor.coadvisor | Ho Min Kim | - |
| dc.date.awarded | 2019-08 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BM 김67 201908 | - |
| dc.date.accepted | 2019-07-01 | - |
| dc.contributor.alternativeDepartment | 뇌인지과학전공 | - |
| dc.embargo.liftdate | 2020-09-01 | - |
| dc.contributor.affiliatedAuthor | Kim, Eun Seon | - |
| dc.contributor.affiliatedAuthor | Kim, Ho Min | - |
| dc.contributor.affiliatedAuthor | Lee, Sung Bae | - |
| dc.contributor.alternativeName | 김호민 | - |
| dc.contributor.alternativeName | 김은선 | - |
| dc.contributor.alternativeName | Sung Bae Lee | - |
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