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dc.contributor.author Lee, A-Rang ko
dc.contributor.author Nam, Kibeom ko
dc.contributor.author Lee, Byeong Jun ko
dc.contributor.author Lee, Seoung-Woo ko
dc.contributor.author Baek, Su-Min ko
dc.contributor.author Bang, Jun-Sun ko
dc.contributor.author Choi, Seong-Kyoon ko
dc.contributor.author Park, Sang-Joon ko
dc.contributor.author Kim, Tae-Hwan ko
dc.contributor.author Jeong, Kyu-Shik ko
dc.contributor.author Lee, Dong Yun ko
dc.contributor.author Park, Jin-Kyu ko
dc.date.accessioned 2019-09-10T07:16:06Z -
dc.date.available 2019-09-10T07:16:06Z -
dc.date.created 2019-08-05 -
dc.date.issued 2019-08 -
dc.identifier.citation International Journal of Molecular Sciences, v.20, no.15 -
dc.identifier.issn 1661-6596 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/10615 -
dc.description.abstract The cellular distribution of silica nanoparticles (NPs) in the liver is not well understood. Targeting specific cells is one of the most important issues in NP-based drug delivery to improve delivery efficacy. In this context, the present study analyzed the relative cellular distribution pattern of silica NPs in the liver, and the effect of surface energy modification on NPs. Hydrophobic NP surface modification enhanced NP delivery to the liver and liver sinusoid fFendothelial cells (LSECs). Conversely, hydrophilic NP surface modification was commensurate with targeting hepatic stellate cells (HSCs) rather than other cell types. There was no notable difference in NP delivery to Kupffer cells or hepatocytes, regardless of hydrophilic or hydrophobic NP surface modification, suggesting that both the targeting of hepatocytes and evasion of phagocytosis by Kupffer cells are not associated with surface energy modification of silica NPs. This study provides useful information to target specific cell types using silica NPs, as well as to understand the relationship between NP surface energy and the NP distribution pattern in the liver, thereby helping to establish strategies for cell targeting using various NPs. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. -
dc.language English -
dc.publisher Multidisciplinary Digital Publishing Institute (MDPI) -
dc.title Hepatic Cellular Distribution of Silica Nanoparticles by Surface Energy Modification -
dc.type Article -
dc.identifier.doi 10.3390/ijms20153812 -
dc.identifier.wosid 000482383000205 -
dc.identifier.scopusid 2-s2.0-85070799950 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.contributor.nonIdAuthor Lee, A-Rang -
dc.contributor.nonIdAuthor Nam, Kibeom -
dc.contributor.nonIdAuthor Lee, Byeong Jun -
dc.contributor.nonIdAuthor Lee, Seoung-Woo -
dc.contributor.nonIdAuthor Baek, Su-Min -
dc.contributor.nonIdAuthor Bang, Jun-Sun -
dc.contributor.nonIdAuthor Park, Sang-Joon -
dc.contributor.nonIdAuthor Kim, Tae-Hwan -
dc.contributor.nonIdAuthor Jeong, Kyu-Shik -
dc.contributor.nonIdAuthor Lee, Dong Yun -
dc.contributor.nonIdAuthor Park, Jin-Kyu -
dc.identifier.citationVolume 20 -
dc.identifier.citationNumber 15 -
dc.identifier.citationTitle International Journal of Molecular Sciences -
dc.type.journalArticle Article -
dc.description.isOpenAccess Y -
dc.subject.keywordAuthor silica nanoparticles -
dc.subject.keywordAuthor surface energy modification -
dc.subject.keywordAuthor NP-based drug delivery -
dc.subject.keywordPlus SINUSOIDAL ENDOTHELIAL-CELLS -
dc.subject.keywordPlus PLASMA-PROTEINS -
dc.subject.keywordPlus STELLATE CELLS -
dc.subject.keywordPlus HEPATOCELLULAR-CARCINOMA -
dc.subject.keywordPlus TARGETED DELIVERY -
dc.subject.keywordPlus INTERFERING RNAS -
dc.subject.keywordPlus SIZE -
dc.subject.keywordPlus HEPATOCYTES -
dc.subject.keywordPlus RECEPTOR -
dc.subject.keywordPlus DISEASE -
dc.contributor.affiliatedAuthor Choi, Seong-Kyoon -
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Appears in Collections:
Division of Biomedical Technology 1. Journal Articles

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