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Carvacrol inhibits cytochrome P450 and protects against binge alcohol-induced liver toxicity

Title
Carvacrol inhibits cytochrome P450 and protects against binge alcohol-induced liver toxicity
Authors
Khan, ImranBhardwaj, MonikaShukla, ShrutiMin, Sang-HyunChoi, Dong KyuBajpai, Vivek K.Huh, Yun SukKang, Sun Chul
Issue Date
2019-09
Citation
Food and Chemical Toxicology, 131
Type
Article
Article Type
Article
Author Keywords
CarvacrolAcute liver injuryCytochrome P450Mice model
Keywords
INDUCED HEPATOTOXICITYOXIDATIVE STRESSINJURYEXPRESSIONPATHWAYRATSPANCREATITISINFLAMMATIONPREVENTIONSTEATOSIS
ISSN
0278-6915
Abstract
Alcoholism is a serious addiction that can lead to various health complications such as liver fibrosis, steatosis, and cirrhosis. Carvacrol is present in many plant-based essential oils and used as a preservative in the food industry. In this study, we have investigated the hepatoprotective role of carvacrol against ethanol-induced liver toxicity in mice. To determine the effect of carvacrol on liver injury parameters, 5 doses of 50% ethanol (10 mL/kg body weight) were orally administered every 12 h for inducing the hepatotoxicity in experimental mice. Interestingly, carvacrol pre-treatment (50 and 100 mg/kg) reversed the ethanol-induced effects on liver function, antioxidant markers, matrix metalloproteinases activities, and histological changes. Moreover, carvacrol binds to the active pocket of cytochrome P450 (Cyt P450) and inhibits its expression. Thus, our finding suggests carvacrol can be used as an adjuvant for the amelioration of alcohol-induced hepatotoxicity. © 2019
URI
http://hdl.handle.net/20.500.11750/10645
DOI
10.1016/j.fct.2019.110582
Publisher
Elsevier BV
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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