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A 3D flexible microelectrode array for subretinal stimulation
- A 3D flexible microelectrode array for subretinal stimulation
- Seo, Hee Won; Kim, Namju; Ahn, Jungryul; Cha, Seongkwang; Goo, Yong Sook; Kim, Sohee
- DGIST Authors
- Kim, Sohee
- Issue Date
- Journal of Neural Engineering, 16(5), 056016
- Article Type
- Author Keywords
- flexible microelectrode array; retinal prosthesis; neural electrodes; 3D electrodes; subretinal stimulation; retinal ganglion cells
- RETINAL GANGLION-CELLS; SUPRACHOROIDAL-TRANSRETINAL STIMULATION; IRIDIUM OXIDE-FILMS; ELECTRICAL-STIMULATION; ELECTRODE ARRAY; BLIND SUBJECTS; PROSTHESIS; PERFORMANCE; ACTIVATION; DEGENERATION
- Objective. Various retinal prostheses have been developed to restore the vision for blind patients, and some of them are already in clinical use. In this paper, we present a three-dimensional (3D) microelectrode array for a subretinal device that can effectively stimulate retinal cells. Approach. To investigate the effect of electrode designs on the electric field distribution, we simulated various electrode shapes and sizes using finite element analysis. Based on the simulation results, the 3D microelectrode array was fabricated and evaluated in in vitro condition. Main results. Through the simulation, we verified that an electrode design of square frustum was effective to stimulate with high contrast. Also, the 3D flexible and transparent microelectrode array based on silicon and polydimethylsiloxane was fabricated using micro-electro-mechanical system technologies. In in vitro experiments, the subretinally positioned 3D microelectrodes properly evoked spikes in retinal ganglion cells. The mean threshold current was 7.4 mu A and the threshold charge density was 33.64 mu C.cm(-2) per phase. Significance. The results demonstrate the feasibility of the fabricated 3D microelectrodes as the subretinal prosthesis. The developed microelectrode array would be integrated with the stimulation circuitry and implanted in animals for further in vivo experiments.
- IOP Publishing
- Related Researcher
Neural Interfaces & MicroSystems Lab
Neural interface; Brain interface; Bio MEMS; Soft MEMS; Stretchable electronics; Zebrafish electrophysiology
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- Department of Robotics EngineeringNeural Interfaces & MicroSystems Lab1. Journal Articles
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