Cited 3 time in webofscience Cited 2 time in scopus

A 3D flexible microelectrode array for subretinal stimulation

Title
A 3D flexible microelectrode array for subretinal stimulation
Authors
Seo, Hee WonKim, NamjuAhn, JungryulCha, SeongkwangGoo, Yong SookKim, Sohee
DGIST Authors
Kim, Sohee
Issue Date
2019-08
Citation
Journal of Neural Engineering, 16(5), 056016
Type
Article
Article Type
Article
Author Keywords
flexible microelectrode arrayretinal prosthesisneural electrodes3D electrodessubretinal stimulationretinal ganglion cells
Keywords
RETINAL GANGLION-CELLSSUPRACHOROIDAL-TRANSRETINAL STIMULATIONIRIDIUM OXIDE-FILMSELECTRICAL-STIMULATIONELECTRODE ARRAYBLIND SUBJECTSPROSTHESISPERFORMANCEACTIVATIONDEGENERATION
ISSN
1741-2560
Abstract
Objective. Various retinal prostheses have been developed to restore the vision for blind patients, and some of them are already in clinical use. In this paper, we present a three-dimensional (3D) microelectrode array for a subretinal device that can effectively stimulate retinal cells. Approach. To investigate the effect of electrode designs on the electric field distribution, we simulated various electrode shapes and sizes using finite element analysis. Based on the simulation results, the 3D microelectrode array was fabricated and evaluated in in vitro condition. Main results. Through the simulation, we verified that an electrode design of square frustum was effective to stimulate with high contrast. Also, the 3D flexible and transparent microelectrode array based on silicon and polydimethylsiloxane was fabricated using micro-electro-mechanical system technologies. In in vitro experiments, the subretinally positioned 3D microelectrodes properly evoked spikes in retinal ganglion cells. The mean threshold current was 7.4 mu A and the threshold charge density was 33.64 mu C.cm(-2) per phase. Significance. The results demonstrate the feasibility of the fabricated 3D microelectrodes as the subretinal prosthesis. The developed microelectrode array would be integrated with the stimulation circuitry and implanted in animals for further in vivo experiments.
URI
http://hdl.handle.net/20.500.11750/10648
DOI
10.1088/1741-2552/ab36ab
Publisher
IOP Publishing
Related Researcher
  • Author Kim, Sohee Neural Interfaces & MicroSystems Lab
  • Research Interests Neural interface; Brain interface; Bio MEMS; Soft MEMS; Stretchable electronics; Zebrafish electrophysiology
Files:
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Collection:
Department of Robotics EngineeringNeural Interfaces & MicroSystems Lab1. Journal Articles


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