Cited 4 time in webofscience Cited 4 time in scopus

Diet restriction-induced healthy aging is mediated through the immune signaling component ZIP-2 in Caenorhabditis elegans

Title
Diet restriction-induced healthy aging is mediated through the immune signaling component ZIP-2 in Caenorhabditis elegans
Authors
Hahm, Jeong-HoonJeong, ChoLongNam, Hong Gil
DGIST Authors
Nam, Hong Gil
Issue Date
2019-10
Citation
Aging Cell, 18(5)
Type
Article
Article Type
Editorial Material; Article
Author Keywords
C. elegansdietary restrictionlongevitymitochondriaTORS6KZIP-2
Keywords
LIFE-SPAN EXTENSIONCALORIE RESTRICTIONC. ELEGANSPHA-4/FOXAPATHWAYTOR
ISSN
1474-9718
Abstract
Dietary restriction (DR) robustly delays the aging process in all animals tested so far. DR slows aging by negatively regulating the target of rapamycin (TOR) and S6 kinase (S6K) signaling pathway and thus inhibiting translation. Translation inhibition in C. elegans is known to activate the innate immune signal ZIP-2. Here, we show that ZIP-2 is activated in response to DR and in feeding-defective eat-2 mutants. Importantly, ZIP-2 contributes to the improvements in longevity and healthy aging, including mitochondrial integrity and physical ability, mediated by DR in C. elegans. We further show that ZIP-2 is activated upon inhibition of TOR/S6K signaling. However, DR-mediated activation of ZIP-2 does not require the TOR/S6K effector PHA-4/FOXA. Furthermore, zip-2 was not activated or required for longevity in daf-2 mutants, which mimic a low nutrition status. Thus, DR appears to activate ZIP-2 independently of PHA-4/FOXA and DAF-2. The link between DR, aging, and immune activation provides practical insight into the DR-induced benefits on health span and longevity. © 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
URI
http://hdl.handle.net/20.500.11750/10660
DOI
10.1111/acel.12982
Publisher
Wiley
Related Researcher
  • Author Nam, Hong Gil CBRG(Complex Biology Research Group)
  • Research Interests Plant Aging and Life History; Systems Biology; Complexbiology; Comparative Aging Research
Files:
Collection:
Department of New BiologyCBRG(Complex Biology Research Group)1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE