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Effects of Gene and Gender on Aggression via Neurophysiological Studies

Title
Effects of Gene and Gender on Aggression via Neurophysiological Studies
Authors
SeungYeong Im
DGIST Authors
Im, SeungYeong; Lee, Chang-HunMoon, Cheil
Advisor(s)
문제일
Co-Advisor(s)
Chang-Hun Lee
Issue Date
2019
Available Date
2019-10-03
Degree Date
2019-02
Type
Thesis
Keywords
분자유전학, 인지신경과학, 인지심리학
Table Of Contents
List of Contents Abstract i List of contents ii List of tables v List of figures vi I. Introduction 1.1 Aggression 1 1.1.1 The need of research on aggression 1 1.1.2 Various forMaster of aggression 2 1.1.3 Assessment of aggression 2 1.1.3.1 Psychological approach 2 1.1.3.2 Behavioural approach 3 1.1.3.3 Neurophysiological/Neurochemical approach 4 1.1.4 Biological/Environmental factors affecting aggression 6 1.2 Genes and aggression 7 1.2.1 Genetics in aggression 7 1.2.2 MAOA (monoamine oxidase A gene) 7 1.2.2.1 MAOA in the studies of aggression 7 1.2.2.2 Structure and function of MAOA 8 1.2.2.3 MAOA uVNTR 8 1.2.2.3.1 Distribution of MAOA uVNTR allele 8 1.2.2.3.2 MAOA uVNTR genotypes and aggression 9 1.2.2.4 Genetic effects of MAOA uVNTR on neurophysiology 10 1.2.2.5 Sex-specificity of MAOA activity and its effects 10 1.3 Gender and aggression 11 1.3.1 Gender difference in aggression 11 1.3.2 Gender difference in neurophysiology of aggression 12 II. Materials & Methods 2.1 Human participants 13 2.2 Preparation of cell lines 13 2.3 Sequencing 14 2.3.1 Genomic DNA extraction 14 2.3.2 PCR (Polymerase chain reaction) 15 2.3.3 PCR product purification 15 2.3.4 Sequence analysis 15 2.4 Preparation for cloning into the promoter fusion vector 17 2.5 DNA transfection and promoter activity assays 17 2.6 Generation of stable cell line fused with MAOA uVNTR alleles 18 2.7 Gel shift assay 18 2.7.1 Preparation of nuclear extracts 18 2.7.2 Chemiluminescent electrophoretic mobility-shift assay 18 2.8 Proteomics 19 2.8.1 Pull-down assay 19 2.8.2 PAGE and Coomassie stain 20 2.8.3 Two-dimensional gel electrophoresis and Master analysis 20 2.8.3.1 In-gel protein digestion 20 2.8.3.2 Peptide Mass Fingerprinting (PMF) 21 2.8.3.3 Identification of proteins by LC-Master/Master 21 2.9 Measurement of neurophysiological responses using EEG/ECG 22 2.9.1 Video stimuli in relation with aggression 22 2.9.2 EEG and ECG recording 24 2.10 Data acquisition of EEG and ECG 25 2.11 Psychological questionnaires of aggression 26 2.12 Statistics 27 III. Neurophysiological correlates of psychological aggression 3.1 Background 28 3.2 Psychological aggression measurement and analysis 29 3.3 Correlation between psychological aggression and aggression-related EEG responses 29 3.4 Correlation between psychological aggression and aggression-related ECG responses 33 3.5 Discussion 34 IV. Genetic effects of MAOA on aggression 4.1 Background 37 4.2 Distribution of MAOA uVNTR in Korean 38 4.3 Transcriptional regulation of MAOA uVNTR 40 4.3.1 Transcriptional efficiency of MAOA uVNTR 40 4.3.2 Transcriptional regulation of MAOA uVNTR 40 4.4 Association between MAOA uVNTR genotype and aggression-related EEG responses 42 4.5 Association between MAOA uVNTR genotype and aggression-related ECG responses 50 4.6 Association between MAOA uVNTR genotype and psychological aggression 50 4.7 Discussion 53 V. Gender difference in aggression 5.1 Background 58 5.2 Association between gender and psychological aggression 59 5.3 Association between gender and aggression-related EEG responses 60 5.4 Association between gender and aggression-related ECG responses 66 5.5 Discussion 67 VI. Conclusion
URI
http://dgist.dcollection.net/common/orgView/200000171521
http://hdl.handle.net/20.500.11750/10680
DOI
10.22677/thesis.200000171521
Degree
DOCTOR
Department
Brain and Cognitive Sciences
University
DGIST
Related Researcher
  • Author Moon, Cheil Laboratory of Chemical Senses
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
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Collection:
Department of Brain and Cognitive SciencesThesesPh.D.


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