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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 유성운 | - |
| dc.contributor.author | Ji-Eun Gim | - |
| dc.date.accessioned | 2019-10-02T16:01:34Z | - |
| dc.date.available | 2019-10-02T16:01:34Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000171529 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/10698 | - |
| dc.description.statementofresponsibility | prohibition | - |
| dc.description.tableofcontents | 1. Introduction 2. Material and Methods 2.1 Cell culture 7 2.2 Western blotting analysis (WB) 7 2.3 RNA extraction and Quantitative real-time polymerase chain reaction (qRT-PCR) 8 2.4 Reagents and antibodies 11 2.5 CORT measurement 11 2.6 Y-maze test 11 2.7 Statistical analysis 12 3. Results 3.1 Generation of PS2 N141I KI mice 13 3.2 Cognitive decline was detected in PS2 N141I KI mice 15 3.3 PS2 CTF levels are decreased in PS2 N141I KI mice 19 3.4 CORT treatment increased PS2 level in HCN cells 21 3.4 PS2 expression in CORT treated HCN cells is regulated by autophagy 23 4. Discussion Reference Abstract in Korean |
- |
| dc.format.extent | 34 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.source | /home/dspace/dspace53/upload/200000171529.pdf | - |
| dc.title | Presenilin-2 N141I Knockin Mice as a Model of Alzheimer’s Disease | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/thesis.200000171529 | - |
| dc.description.degree | MASTER | - |
| dc.contributor.department | Brain and Cognitive Sciences | - |
| dc.identifier.bibliographicCitation | Ji-Eun Gim. (2019). Presenilin-2 N141I Knockin Mice as a Model of Alzheimer’s Disease. doi: 10.22677/thesis.200000171529 | - |
| dc.contributor.coadvisor | Byung-Hoon Lee | - |
| dc.date.awarded | 2019-02 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BM 김78 201902 | - |
| dc.date.accepted | 2019-01-30 | - |
| dc.contributor.alternativeDepartment | 뇌인지과학전공 | - |
| dc.embargo.liftdate | 2024-01-04 | - |
| dc.contributor.affiliatedAuthor | Yu, Seong-Woon | - |
| dc.contributor.affiliatedAuthor | Gim, Ji-Eun | - |
| dc.contributor.affiliatedAuthor | Lee, Byung-Hoon | - |
| dc.contributor.alternativeName | 이병훈 | - |
| dc.contributor.alternativeName | Seong-woon Yu | - |
| dc.contributor.alternativeName | 김지은 | - |
