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Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling
- Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling
- Nguyen, Quy Thi Cam; Lee, Sun-ji; Choi, Seo-wha; Na, Yeon-ju; Song, Mi-ran; Hoang, Quyen Thi Ngoc; Sim, Seo Young; Kim, Min-Sik; Kim, Jeong-Il; Soh, Moon-Soo; Kim, Soo Young
- DGIST Authors
- Kim, Min-Sik
- Issue Date
- Molecules and Cells, 42(9), 646-660
- Article Type
- Author Keywords
- ABI5; abscisic acid; phytohormone; Raf10; signaling; SnRK2s
- SNRK2 PROTEIN-KINASES; DIFFERENT PHOSPHORYLATION MECHANISMS; ABSCISIC-ACID ABA; TRANSCRIPTION FACTORS; GENE-EXPRESSION; OSMOTIC-STRESS; POSITIVE REGULATORS; PHOSPHATASES 2C; BINDING; TRANSDUCTION
- Abscisic acid (ABA) is a phytohormone essential for seed development and seedling growth under unfavorable environmental conditions. The signaling pathway leading to ABA response has been established, but relatively little is known about the functional regulation of the constituent signaling components. Here, we present several lines of evidence that Arabidopsis Raf-like kinase Raf10 modulates the core ABA signaling downstream of signal perception step. In particular, Raf10 phosphorylates subclass III SnRK2s (SnRK2.2, SnRK2.3, and SnRK2.6), which are key positive regulators, and our study focused on SnRK2.3 indicates that Raf10 enhances its kinase activity and may facilitate its release from negative regulators. Raf10 also phosphorylates transcription factors (ABI5, ABF2, and ABI3) critical for ABA-regulted gene expression. Furthermore, Raf10 was found to be essential for the in vivo functions of SnRK2s and ABI5. Collectively, our data demonstrate that Raf10 is a novel regulatory component of core ABA signaling.
- Related Researcher
Laboratory for QBIO and Precision Medicine
Cancer Proteogenomics, Biomarker Discovery, Integrative Multi-Omics
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- Department of New BiologyLaboratory for QBIO and Precision Medicine1. Journal Articles
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