Cited 15 time in webofscience Cited 16 time in scopus

Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling

Title
Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling
Authors
Nguyen, Quy Thi CamLee, Sun-jiChoi, Seo-whaNa, Yeon-juSong, Mi-ranHoang, Quyen Thi NgocSim, Seo YoungKim, Min-SikKim, Jeong-IlSoh, Moon-SooKim, Soo Young
DGIST Authors
Kim, Min-Sik
Issue Date
2019-09
Citation
Molecules and Cells, 42(9), 646-660
Type
Article
Article Type
Article
Author Keywords
ABI5abscisic acidphytohormoneRaf10signalingSnRK2s
Keywords
SNRK2 PROTEIN-KINASESDIFFERENT PHOSPHORYLATION MECHANISMSABSCISIC-ACID ABATRANSCRIPTION FACTORSGENE-EXPRESSIONOSMOTIC-STRESSPOSITIVE REGULATORSPHOSPHATASES 2CBINDINGTRANSDUCTION
ISSN
1016-8478
Abstract
Abscisic acid (ABA) is a phytohormone essential for seed development and seedling growth under unfavorable environmental conditions. The signaling pathway leading to ABA response has been established, but relatively little is known about the functional regulation of the constituent signaling components. Here, we present several lines of evidence that Arabidopsis Raf-like kinase Raf10 modulates the core ABA signaling downstream of signal perception step. In particular, Raf10 phosphorylates subclass III SnRK2s (SnRK2.2, SnRK2.3, and SnRK2.6), which are key positive regulators, and our study focused on SnRK2.3 indicates that Raf10 enhances its kinase activity and may facilitate its release from negative regulators. Raf10 also phosphorylates transcription factors (ABI5, ABF2, and ABI3) critical for ABA-regulted gene expression. Furthermore, Raf10 was found to be essential for the in vivo functions of SnRK2s and ABI5. Collectively, our data demonstrate that Raf10 is a novel regulatory component of core ABA signaling.
URI
http://hdl.handle.net/20.500.11750/10775
DOI
10.14348/molcells.2019.0173
Publisher
한국분자세포생물학회
Related Researcher
  • Author Kim, Min-Sik Laboratory for QBIO and Precision Medicine
  • Research Interests Cancer Proteogenomics, Biomarker Discovery, Integrative Multi-Omics
Files:
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Collection:
Department of New BiologyLaboratory for QBIO and Precision Medicine1. Journal Articles


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