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Balanced actions of protein synthesis and degradation in memory formation

Title
Balanced actions of protein synthesis and degradation in memory formation
Authors
Park, HyungjuKaang, Bong-Kiun
Issue Date
2019-09
Citation
Learning and Memory, 26(9), 299-306
Type
Article
Article Type
Review
Keywords
LONG-TERM POTENTIATIONMENTAL-RETARDATION PROTEINFRAGILE-XSYNAPTIC PLASTICITYEPIGENETIC MECHANISMSMOLECULAR-MECHANISMNEUROTROPHIC FACTORNEGATIVE REGULATORAXONAL-TRANSPORTSENSORY NEURONS
ISSN
1072-0502
Abstract
Storage of long-term memory requires not only protein synthesis but also protein degradation. In this article, we overview recent publications related to this issue, stressing that the balanced actions of protein synthesis and degradation are critical for long-term memory formation. We particularly focused on the brain-derived neurotrophic factor signaling that leads to protein synthesis; proteasome- and autophagy-dependent protein degradation that removes molecular constraints; the role of Fragile X mental retardation protein in translational suppression; and epigenetic modifications that control gene expression at the genomic level. Numerous studies suggest that an imbalance between protein synthesis and degradation leads to intellectual impairment and cognitive disorders. © 2019 Park and Kaang; Published by Cold Spring Harbor Laboratory Press.
URI
http://hdl.handle.net/20.500.11750/10795
DOI
10.1101/lm.048785.118
Publisher
Cold Spring Harbor Laboratory Press
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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