Magnetically Actuated SiCN-Based Ceramic Microrobot for Guided Cell Delivery
- Title
- Magnetically Actuated SiCN-Based Ceramic Microrobot for Guided Cell Delivery
- Author(s)
- Gyak, Ki-Won ; Jeon, S. ; Ha, Laura ; Kim, Sang Won ; Kim, Jin-Young ; Lee, K.-S. ; Choi, H. ; Kim, Dong-Pyo
- DGIST Authors
- Kim, Jin-Young ; Choi, H.
- Issued Date
- 2019-11
- Type
- Article
- Article Type
- Article
- Author Keywords
- biocompatible materials ; cell delivery ; ceramic microrobots ; magnetic nanoparticles ; silicon carbonitride
- Keywords
- FABRICATION
- ISSN
- 2192-2640
- Abstract
- A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by 3D laser lithography using a photocurable preceramic polymer, chemically modified polyvinylsilazane, and subsequent pyrolysis at 600 °C under an inert atmosphere. Magnetic nanoparticles (MNP) are integrated into the surface-modified ceramic carrier by thiol-ene click reaction. Finally, the microrobot is loaded with fibroblast cells, which can be guided by a rotating external magnetic field. The proposed ceramic microrobot is mechanically durable, adequately controllable with external magnetic field, and quite compatible with mammalian cells. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- Publisher
- Wiley-VCH Verlag
- Related Researcher
-
-
Kim, Jin-young
- Research Interests
-
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- Appears in Collections:
- Department of Robotics and Mechatronics Engineering Bio-Micro Robotics Lab 1. Journal Articles
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