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Synthetic Strategies for (−)-Cannabidiol and Its Structural Analogs

Title
Synthetic Strategies for (−)-Cannabidiol and Its Structural Analogs
Authors
Jung, ByunghyuckLee, Jungkyu K.Kim, JungnamKang, Eunhye K.Lee, Hee-YoonHan, Sang YeongChoi, Insung S.
DGIST Authors
Jung, Byunghyuck
Issue Date
2019-11
Citation
Chemistry - An Asian Journal, 14(21), 3749-3762
Type
Article
Article Type
Review
Author Keywords
(−)-cannabidiolcannabidiol analogshemp plantmedical marijuanatherapeutic effects
Keywords
PLANT CANNABINOID CANNABIGEROLFIBER-TYPE CANNABISCLAISEN REARRANGEMENTMOLECULAR TARGETSDERIVATIVESRECEPTORACIDEPILEPSYOXIDATIONARYLATION
ISSN
1861-4728
Abstract
(−)-Cannabidiol ((−)-CBD), a non-psychoactive phytocannabinoid from Cannabis, and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti-epileptic, anti-inflammatory, anxiolytic, and anti-cancer properties. (−)-CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction-based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical-synthetic strategies for (−)-CBD could tackle these issues, and, additionally, generate novel (−)-CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (−)-CBD and its analogs. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
http://hdl.handle.net/20.500.11750/10919
DOI
10.1002/asia.201901179
Publisher
Wiley-VCH Verlag
Related Researcher
  • Author Jung, Byunghyuck Asymmetric Organic Synthesis and Drug Synthesis Laboratory
  • Research Interests Organic Synthesis; Organo-transition metal chemistry; Catalytic Asymmetric Synthesis; Synthetic Methodologies; Synthesis of Natural Products and Drugs
Files:
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Collection:
Department of Emerging Materials ScienceAsymmetric Organic Synthesis and Drug Synthesis Laboratory1. Journal Articles


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