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Synthetic Strategies for (−)-Cannabidiol and Its Structural Analogs
- Synthetic Strategies for (−)-Cannabidiol and Its Structural Analogs
- Jung, Byunghyuck; Lee, Jungkyu K.; Kim, Jungnam; Kang, Eunhye K.; Lee, Hee-Yoon; Han, Sang Yeong; Choi, Insung S.
- DGIST Authors
- Jung, Byunghyuck
- Issue Date
- Chemistry - An Asian Journal, 14(21), 3749-3762
- Article Type
- Author Keywords
- (−)-cannabidiol; cannabidiol analogs; hemp plant; medical marijuana; therapeutic effects
- PLANT CANNABINOID CANNABIGEROL; FIBER-TYPE CANNABIS; CLAISEN REARRANGEMENT; MOLECULAR TARGETS; DERIVATIVES; RECEPTOR; ACID; EPILEPSY; OXIDATION; ARYLATION
- (−)-Cannabidiol ((−)-CBD), a non-psychoactive phytocannabinoid from Cannabis, and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti-epileptic, anti-inflammatory, anxiolytic, and anti-cancer properties. (−)-CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction-based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical-synthetic strategies for (−)-CBD could tackle these issues, and, additionally, generate novel (−)-CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (−)-CBD and its analogs. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
- Wiley-VCH Verlag
- Related Researcher
Asymmetric Organic Synthesis and Drug Synthesis Laboratory
Organic Synthesis; Organo-transition metal chemistry; Catalytic Asymmetric Synthesis; Synthetic Methodologies; Synthesis of Natural Products and Drugs
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- Department of Emerging Materials ScienceAsymmetric Organic Synthesis and Drug Synthesis Laboratory1. Journal Articles
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