Department of Physics and Chemistry
Asymmetric Organic Synthesis and Drug Synthesis Laboratory
1. Journal Articles
Synthetic Strategies for (−)-Cannabidiol and Its Structural Analogs
- Title
- Synthetic Strategies for (−)-Cannabidiol and Its Structural Analogs
- Author(s)
- Jung, Byunghyuck ; Lee, Jungkyu K. ; Kim, Jungnam ; Kang, Eunhye K. ; Lee, Hee-Yoon ; Han, Sang Yeong ; Choi, Insung S.
- DGIST Authors
- Jung, Byunghyuck
- Issued Date
- 2019-11
- Type
- Article
- Article Type
- Review
- Author Keywords
- (−)-cannabidiol ; cannabidiol analogs ; hemp plant ; medical marijuana ; therapeutic effects
- Keywords
- PLANT CANNABINOID CANNABIGEROL ; FIBER-TYPE CANNABIS ; CLAISEN REARRANGEMENT ; MOLECULAR TARGETS ; DERIVATIVES ; RECEPTOR ; ACID ; EPILEPSY ; OXIDATION ; ARYLATION
- ISSN
- 1861-4728
- Abstract
- (−)-Cannabidiol ((−)-CBD), a non-psychoactive phytocannabinoid from Cannabis, and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti-epileptic, anti-inflammatory, anxiolytic, and anti-cancer properties. (−)-CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction-based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical-synthetic strategies for (−)-CBD could tackle these issues, and, additionally, generate novel (−)-CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (−)-CBD and its analogs. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
- Publisher
- Wiley-VCH Verlag
- Related Researcher
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Jung, Byunghyuck
- Research Interests Organic Synthesis; Organo-transition metal chemistry; Catalytic Asymmetric Synthesis; Synthetic Methodologies; Synthesis of Natural Products and Drugs
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