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Synthetic Strategies for (−)-Cannabidiol and Its Structural Analogs
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- Title
- Synthetic Strategies for (−)-Cannabidiol and Its Structural Analogs
- DGIST Authors
- Jung, Byunghyuck
- Issued Date
- 2019-11
- Citation
- Jung, Byunghyuck. (2019-11). Synthetic Strategies for (−)-Cannabidiol and Its Structural Analogs. doi: 10.1002/asia.201901179
- Type
- Article
- Article Type
- Review
- Author Keywords
- (−)-cannabidiol ; cannabidiol analogs ; hemp plant ; medical marijuana ; therapeutic effects
- Keywords
- PLANT CANNABINOID CANNABIGEROL ; FIBER-TYPE CANNABIS ; CLAISEN REARRANGEMENT ; MOLECULAR TARGETS ; DERIVATIVES ; RECEPTOR ; ACID ; EPILEPSY ; OXIDATION ; ARYLATION
- ISSN
- 1861-4728
- Abstract
-
(−)-Cannabidiol ((−)-CBD), a non-psychoactive phytocannabinoid from Cannabis, and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti-epileptic, anti-inflammatory, anxiolytic, and anti-cancer properties. (−)-CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction-based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical-synthetic strategies for (−)-CBD could tackle these issues, and, additionally, generate novel (−)-CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (−)-CBD and its analogs. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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- Publisher
- Wiley-VCH Verlag
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