Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Do, Hyun Ju | ko |
dc.contributor.author | Hwang, Yeo Jin | ko |
dc.contributor.author | Yang, Hye Jin | ko |
dc.contributor.author | Park, Kwang Il | ko |
dc.date.accessioned | 2019-12-12T08:35:55Z | - |
dc.date.available | 2019-12-12T08:35:55Z | - |
dc.date.created | 2019-11-07 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | Evidence-based Complementary and Alternative Medicine, v.2019 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/10924 | - |
dc.description.abstract | Rhus verniciflua is widely known for its antioxidant, antibacterial, anticancer, and antiaging efficacy and α-lucosidase inhibition. This study was designed whether Rhus verniciflua extracts inhibit the IgE-antigen-mediated allergic reaction in RBL-2H3 mast cells, and it further investigated the FcϵRI- and arachidonate-signaling by which Rhus verniciflua extracts exert its antiallergic effects. IgE-antigen-sensitized RBL-2H3 mast cells were investigated for the cytotoxicity of Rhus verniciflua extracts and β-hexosaminidase release, and inflammatory mediators(e.g., TNF-α, IL-4, IL-6, histamine, and PGD2)were then assessed. Additionally, we examined expressions of genes involved in arachidonate- and FcϵRI-signaling pathway in RBL-2H3. Rhus verniciflua extracts inhibited β-hexosaminidase release and production of the inflammatory mediators in RBL-2H3. Rhus verniciflua extracts reduced amounts of histamine and expressions of FcϵRI signaling-related genes such as Lyn and Syk and phosphorylation of extracellular signal-regulated kinase in mast cells. Finally, in late allergic responses, Rhus verniciflua extracts reduced PGD2 release and COX-2 and cPLA2 phosphorylation expressions from IgE-antigen-mediated mast cells. Lastly, 250-500 mg/kg RVE significantly attenuated the Ag/IgE-induced passive cutaneous anaphylaxis (PCA) reaction in mice. These findings provide novel information on the molecular mechanisms underlying the antiallergy properties of Rhus verniciflua extracts in FcϵRI-mediated allergic reaction. © 2019 Hyun Ju Do et al. | - |
dc.language | English | - |
dc.publisher | Hindawi Limited | - |
dc.title | Effect of Rhus verniciflua Extract on IgE-Antigen-Mediated Allergic Reaction in Rat Basophilic Leukemic RBL-2H3 Mast Cells and Passive Cutaneous Anaphylaxis in Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1155/2019/6497691 | - |
dc.identifier.wosid | 000493110600002 | - |
dc.identifier.scopusid | 2-s2.0-85074238603 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Do, Hyun Ju | - |
dc.contributor.nonIdAuthor | Yang, Hye Jin | - |
dc.contributor.nonIdAuthor | Park, Kwang Il | - |
dc.identifier.citationVolume | 2019 | - |
dc.identifier.citationTitle | Evidence-based Complementary and Alternative Medicine | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | FC-EPSILON-RI | - |
dc.subject.keywordPlus | DEGRANULATION | - |
dc.subject.keywordPlus | STOKES | - |
dc.subject.keywordPlus | SYK | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | IL-4 | - |
dc.contributor.affiliatedAuthor | Hwang, Yeo Jin | - |