Cited 0 time in webofscience Cited 1 time in scopus

DDS promotes longevity through a microbiome-mediated starvation signal

Title
DDS promotes longevity through a microbiome-mediated starvation signal
Authors
Choi, HaeriCho, Sung ChunHa, Young WanOcampo, BilliePark, ShirleyChen, ShiwenBennett, Christopher F.Han, JeehaeRossner, RyanKang, Jong-SunLee, Yun-IlPark, Sang ChulKaeberlein, Matt
DGIST Authors
Lee, Yun-Il
Issue Date
2019-07
Citation
Translational Medicine of Aging, 3, 64-69
Type
Article
Article Type
Article
Keywords
dapsonefolic acidmetforminmethioninequercetinunspecific monooxygenaseArticlebacterial growthCaenorhabditis eleganscontrolled studydiet restrictionhypoxialeprosylife extensionlongevitymetabolitemicrobiomenonhumanstarvation
ISSN
2468-5011
Abstract
The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2. © 2019 KeAi Communications Co., Ltd
URI
http://hdl.handle.net/20.500.11750/11616
DOI
10.1016/j.tma.2019.07.001
Publisher
KeAi Communications Co.
Related Researcher
Files:
There are no files associated with this item.
Collection:
Division of Biotechnology1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE