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DDS promotes longevity through a microbiome-mediated starvation signal
- DDS promotes longevity through a microbiome-mediated starvation signal
- Choi, Haeri; Cho, Sung Chun; Ha, Young Wan; Ocampo, Billie; Park, Shirley; Chen, Shiwen; Bennett, Christopher F.; Han, Jeehae; Rossner, Ryan; Kang, Jong-Sun; Lee, Yun-Il; Park, Sang Chul; Kaeberlein, Matt
- DGIST Authors
- Lee, Yun-Il
- Issue Date
- Translational Medicine of Aging, 3, 64-69
- Article Type
- dapsone; folic acid; metformin; methionine; quercetin; unspecific monooxygenase; Article; bacterial growth; Caenorhabditis elegans; controlled study; diet restriction; hypoxia; leprosy; life extension; longevity; metabolite; microbiome; nonhuman; starvation
- The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2. © 2019 KeAi Communications Co., Ltd
- KeAi Communications Co.
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- Division of Biotechnology1. Journal Articles
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