Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Jin-Woo | ko |
dc.contributor.author | Lim, Sung-Ho | ko |
dc.contributor.author | Kim, Bomin | ko |
dc.contributor.author | Kim, Eunho | ko |
dc.contributor.author | Kim, Kyungsoo | ko |
dc.contributor.author | Park, Sung Kyu | ko |
dc.contributor.author | Byun, Young Seok | ko |
dc.contributor.author | Sakong, Joon | ko |
dc.contributor.author | Choi, Ji-Woong | ko |
dc.date.accessioned | 2020-04-13T06:23:16Z | - |
dc.date.available | 2020-04-13T06:23:16Z | - |
dc.date.created | 2020-03-31 | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | Biomedical Optics Express, v.11, no.4, pp.1725 - 1741 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/11665 | - |
dc.description.abstract | Cognitive decline (CD) is a major symptom of mild cognitive impairment (MCI). Patients with MCI have an increased likelihood of developing Alzheimer's disease (AD). Although a cure for AD is currently lacking, medication therapies and/or daily training in the early stage can alleviate disease progression and improve patients' quality of life. Accordingly, investigating CD-related biomarkers via brain imaging devices is crucial for early diagnosis. In particular, “portable” brain imaging devices enable frequent diagnostic checks as a routine clinical tool, and therefore increase the possibility of early AD diagnosis. This study aimed to comprehensively investigate functional connectivity (FC) in the prefrontal cortex measured by a portable functional near-infrared spectroscopy (fNIRS) device during a working memory (WM) task known as the delayed matching to sample (DMTS) task. Differences in prefrontal FC between healthy control (HC) (n = 23) and CD groups (n = 23) were examined. Intra-group analysis (one-sample t-test) revealed significantly greater prefrontal FC, especially left- and inter-hemispheric FC, in the CD group than in the HC. These observations could be due to a compensatory mechanism of the prefrontal cortex caused by hippocampal degeneration. Inter-group analysis (unpaired two-sample t-test) revealed significant intergroup differences in left- and inter-hemispheric FC. These attributes may serve as a novel biomarker for early detection of MCI. In addition, our findings imply that portable fNIRS devices covering the prefrontal cortex may be useful for early diagnosis of MCI. © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement | - |
dc.language | English | - |
dc.publisher | Optical Society of America | - |
dc.title | Prefrontal functional connectivity analysis of cognitive decline for early diagnosis of mild cognitive impairment: A functional near-infrared spectroscopy study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1364/BOE.382197 | - |
dc.identifier.wosid | 000523980200002 | - |
dc.identifier.scopusid | 2-s2.0-85082818813 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Park, Sung Kyu | - |
dc.contributor.nonIdAuthor | Byun, Young Seok | - |
dc.contributor.nonIdAuthor | Sakong, Joon | - |
dc.identifier.citationVolume | 11 | - |
dc.identifier.citationNumber | 4 | - |
dc.identifier.citationStartPage | 1725 | - |
dc.identifier.citationEndPage | 1741 | - |
dc.identifier.citationTitle | Biomedical Optics Express | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | WORKING-MEMORY | - |
dc.subject.keywordPlus | EXECUTIVE FUNCTIONS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | FNIRS | - |
dc.subject.keywordPlus | MCI | - |
dc.subject.keywordPlus | ATTENTION | - |
dc.subject.keywordPlus | TISSUE | - |
dc.contributor.affiliatedAuthor | Choi, Ji-Woong | - |