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  Department of New Biology Aging, Metabolism and Physiology Lab

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Article
Engineered extracellular vesicles with surface FGF21 and enclosed miR-223 for treating metabolic dysfunction-associated steatohepatitis
  • Cho, Hanchae ; 
  • Ju, Hyunji ; 
  • Ahn, Yongdeok ; 
  • Jang, Juhee ; 
  • Cho, Juhyeong ; 
  • Park, Eunju ; 
  • Kang, Sung-Min ; 
  • Lee, Jaemin ; 
  • Seo, Daeha ; 
  • Baek, Moon-Chang ; 
    • et al
  • 2025-10
  • Cho, Hanchae. (2025-10). Engineered extracellular vesicles with surface FGF21 and enclosed miR-223 for treating metabolic dysfunction-associated steatohepatitis. Biomaterials, 321. doi: 10.1016/j.biomaterials.2025.123321
  • Elsevier
  • View : 409
  • Download : 0

Exploring Renal Pyruvate Metabolism as a Therapeutic Avenue for Diabetic Kidney Injury

Article
Exploring Renal Pyruvate Metabolism as a Therapeutic Avenue for Diabetic Kidney Injury
  • 2024-05
  • Diabetes & Metabolism Journal, v.48, no.3, pp.385 - 386
  • 대한당뇨병학회
  • View : 130
  • Download : 19

ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets

Article
ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets
  • Gao, Yurong ; 
  • Ryu, Hanguk ; 
  • Lee, Hyejin ; 
  • Kim, Young-Joon ; 
  • Lee, Ji-Hye ; 
  • Lee, Jaemin
  • 2024-01
  • Gao, Yurong. (2024-01). ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets. Molecules and Cells, 47(1), 1–11. doi: 10.1016/j.mocell.2023.12.002
  • Elsevier
  • View : 286
  • Download : 42

Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis

Article
Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis
  • Jung, Su-Ryun ; 
  • Lee, Ji-Hye ; 
  • Ryu, Hanguk ; 
  • Gao, Yurong ; 
  • Lee, Jaemin
  • 2024-01
  • Jung, Su-Ryun. (2024-01). Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis. Korean Journal of Physiology & Pharmacology, 28(1), 31–38. doi: 10.4196/kjpp.2024.28.1.31
  • the Korean Physiological Society (KPS) and the Korean Society of Pharmacology (KSP)
  • View : 358
  • Download : 45
Article
Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression
  • Lee, Ji-Hye ; 
  • Ryu, Hanguk ; 
  • Lee, Hyejin ; 
  • Yu, Hye Ram ; 
  • Gao, Yurong ; 
  • Lee, Kyeong-Min ; 
  • Kim, Young-Joon ; 
  • Lee, Jaemin
  • 2023-11
  • Lee, Ji-Hye. (2023-11). Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression. American Journal of Physiology - Endocrinology and Metabolism, 325(5), E448–E465. doi: 10.1152/ajpendo.00156.2023
  • American Physiological Society
  • View : 321
  • Download : 0
Article
곤충 insulin-like peptide의 생리 조절 작용
  • 2022-03
  • 김두경. (2022-03). 곤충 insulin-like peptide의 생리 조절 작용. doi: 10.5656/KSAE.2022.02.0.016
  • 한국응용곤충학회
  • View : 320
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Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic beta-Cell Dysfunction and Senescence in Type 2 Diabetes

Article
Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic beta-Cell Dysfunction and Senescence in Type 2 Diabetes
  • 2022-05
  • Lee, Ji-Hye. (2022-05). Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic beta-Cell Dysfunction and Senescence in Type 2 Diabetes. International Journal of Molecular Sciences, 23(9). doi: 10.3390/ijms23094843
  • MDPI
  • View : 419
  • Download : 93

The Common Cellular Events in the Neurodegenerative Diseases and the Associated Role of Endoplasmic Reticulum Stress

Article
The Common Cellular Events in the Neurodegenerative Diseases and the Associated Role of Endoplasmic Reticulum Stress
  • Kim, Soojeong ; 
  • Kim, Doo Kyung ; 
  • Jeong, Seho ; 
  • Lee, Jaemin
  • 2022-06
  • Kim, Soojeong. (2022-06). The Common Cellular Events in the Neurodegenerative Diseases and the Associated Role of Endoplasmic Reticulum Stress. International Journal of Molecular Sciences, 23(11). doi: 10.3390/ijms23115894
  • MDPI
  • View : 483
  • Download : 64
Article
Antiobesity therapeutics with complementary dual-agonist activities at glucagon and glucagon-like peptide 1 receptors
  • Park, Bong Gyu ; 
  • Kim, Gyeong Min ; 
  • Lee, Hye-Jin ; 
  • Ryu, Jae Ha ; 
  • Kim, Dong-Hoon ; 
  • Seong, Jae-Young ; 
  • Kim, Soojeong ; 
  • Park, Zee-Yong ; 
  • Kim, Young-Joon ; 
  • Lee, Jaemin ; 
    • et al
  • 2022-01
  • Park, Bong Gyu. (2022-01). Antiobesity therapeutics with complementary dual-agonist activities at glucagon and glucagon-like peptide 1 receptors. Diabetes, Obesity and Metabolism, 24(1), 50–60. doi: 10.1111/dom.14546
  • John Wiley and Sons Inc
  • View : 555
  • Download : 0

Cellular Stress-Modulating Drugs Can Potentially Be Identified by in Silico Screening with Connectivity Map (CMap)

Article
Cellular Stress-Modulating Drugs Can Potentially Be Identified by in Silico Screening with Connectivity Map (CMap)
  • 2019-11
  • Gao, Yu Rong. (2019-11). Cellular Stress-Modulating Drugs Can Potentially Be Identified by in Silico Screening with Connectivity Map (CMap). International Journal of Molecular Sciences, 20(22). doi: 10.3390/ijms20225601
  • Multidisciplinary Digital Publishing Institute (MDPI)
  • View : 768
  • Download : 112

Amelioration of Mitochondrial Quality Control and Proteostasis by Natural Compounds in Parkinson’s Disease Models

Article
Amelioration of Mitochondrial Quality Control and Proteostasis by Natural Compounds in Parkinson’s Disease Models
  • 2019-10
  • Cho, Bongki. (2019-10). Amelioration of Mitochondrial Quality Control and Proteostasis by Natural Compounds in Parkinson’s Disease Models. International Journal of Molecular Sciences, 20(20), 5208. doi: 10.3390/ijms20205208
  • Multidisciplinary Digital Publishing Institute (MDPI)
  • View : 738
  • Download : 114

PGC-1 alpha functions as a co-suppressor of XBP1 s to regulate glucose metabolism

Article
PGC-1 alpha functions as a co-suppressor of XBP1 s to regulate glucose metabolism
  • Lee, Jae Min ; 
  • Salazar Hernández, Mario Andrés ; 
  • Auen, Thomas ; 
  • Mucka, Patrick ; 
  • Lee, Justin ; 
  • Ozcan, Umut
  • 2018-01
  • Lee, Jae Min. (2018-01). PGC-1 alpha functions as a co-suppressor of XBP1 s to regulate glucose metabolism. Molecular Metabolism, 7, 119–131. doi: 10.1016/j.molmet.2017.10.010
  • Elsevier GmbH
  • View : 795
  • Download : 89
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