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A cellular surveillance and defense system that delays aging phenotypes in C. elegans

Title
A cellular surveillance and defense system that delays aging phenotypes in C. elegans
Authors
Hahm, Jeong-HoonJeong, ChoLongLee, Won HeeKoo, Hee JungKim, SunheeHwang, DaeheeNam, Hong Gil
DGIST Authors
Hahm, Jeong-Hoon; Jeong, ChoLong; Lee, Won Hee; Koo, Hee Jung; Kim, Sunhee; Hwang, Daehee; Nam, Hong Gil
Issue Date
2020-04
Citation
Aging-US, 12(9), 8202-8220
Type
Article
Article Type
Article
Author Keywords
C. elegansZIP-2agingcompensationmitochondria
Keywords
MITOCHONDRIAL DYSFUNCTIONPATHOGENMUSCLEACCUMULATIONMUTATIONSDELETIONSRECEPTORBRAIN
ISSN
1945-4589
Abstract
Physiological stresses, such as pathogen infection, are detected by "cellular Surveillance Activated Detoxification and Defenses" (cSADD) systems that trigger host defense responses. Aging is associated with physiological stress, including impaired mitochondrial function. Here, we investigated whether an endogenous cSADD pathway is activated during aging in C. elegans. We provide evidence that the transcription factor ZIP-2, a well-known immune response effector in C. elegans, is activated in response to age-associated mitochondrial dysfunction. ZIP-2 mitigates multiple aging phenotypes, including mitochondrial disintegration and reduced motility of the pharynx and intestine. Importantly, our data suggest that ZIP-2 is activated during aging independently of bacterial infection and of the transcription factors ATFS-1 and CEBP-2. Thus, ZIP-2 is a key component of an endogenous pathway that delays aging phenotypes in C. elegans. Our data suggest that aging coopted a compensatory strategy for regulation of aging process as a guarded process rather than a simple passive deterioration process. © Hahm et al.
URI
http://hdl.handle.net/20.500.11750/11895
DOI
10.18632/aging.103134
Publisher
Impact Journals
Related Researcher
  • Author Nam, Hong Gil CBRG(Complex Biology Research Group)
  • Research Interests Plant Aging and Life History; Systems Biology; Complexbiology; Comparative Aging Research
Files:
Collection:
Department of New BiologyCBRG(Complex Biology Research Group)1. Journal Articles


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