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Identification of Novel Rodent Proprioceptive receptor Using Proprioceptor-Specific CRISPR/Cas9 Genome Editing

Title
Identification of Novel Rodent Proprioceptive receptor Using Proprioceptor-Specific CRISPR/Cas9 Genome Editing
Author(s)
Eujung Kim
DGIST Authors
Kim, EujungKim, KyuhyungChoe, Han Kyoung
Advisor
최한경
Co-Advisor(s)
Kyuhyung Kim
Issued Date
2020
Awarded Date
2020-02
Type
Thesis
Description
Proprioception, Proprioceptive receptor, CRISPR/Cas9,
Table Of Contents
I. Introduction 1
II. Materials and Methods 4
III. Results 8
3.1 Evolutionally conserved TRP channel family from C. elegans to Human. 8
3.2 Production of CRISPR/Cas9-mediated knockdown vector against ortholog genes of C. elegans proprioceptive channels. 8
3.3 Establishment of intrathecal AAV delivery to the DRG. 9
3.4 Characterization of proprioception-related behavioral phenotype. 10
3.5 In vivo AAV-gRNA delivery and behavior results. 11
IV. Discussion 23
V. References 26
URI
http://dgist.dcollection.net/common/orgView/200000285830

http://hdl.handle.net/20.500.11750/11913
DOI
10.22677/Theses.200000285830
Degree
Master
Department
Brain and Cognitive Sciences
Publisher
DGIST
Related Researcher
  • 김규형 Kim, Kyuhyung 뇌과학과
  • Research Interests Neurobehavior; Neural Circuit; Neurodevelopment; 신경회로; 신경행동; 신경발생; 신경유전학
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Department of Brain Sciences Theses Master

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