Identification of Novel Rodent Proprioceptive receptor Using Proprioceptor-Specific CRISPR/Cas9 Genome Editing
- Title
- Identification of Novel Rodent Proprioceptive receptor Using Proprioceptor-Specific CRISPR/Cas9 Genome Editing
- Author(s)
- Eujung Kim
- DGIST Authors
- Choe, Han Kyoung ; Kim, Eujung ; Kim, Kyuhyung
- Advisor
- 최한경
- Co-Advisor(s)
- Kyuhyung Kim
- Issued Date
- 2020
- Awarded Date
- 2020-02
- Type
- Thesis
- Description
- Proprioception, Proprioceptive receptor, CRISPR/Cas9,
- Table Of Contents
-
I. Introduction 1
II. Materials and Methods 4
III. Results 8
3.1 Evolutionally conserved TRP channel family from C. elegans to Human. 8
3.2 Production of CRISPR/Cas9-mediated knockdown vector against ortholog genes of C. elegans proprioceptive channels. 8
3.3 Establishment of intrathecal AAV delivery to the DRG. 9
3.4 Characterization of proprioception-related behavioral phenotype. 10
3.5 In vivo AAV-gRNA delivery and behavior results. 11
IV. Discussion 23
V. References 26
- URI
-
http://dgist.dcollection.net/common/orgView/200000285830
http://hdl.handle.net/20.500.11750/11913
- Degree
- Master
- Department
- Brain and Cognitive Sciences
- Publisher
- DGIST
- Related Researcher
-
-
Choe, Han Kyoung
- Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
-
- Files in This Item:
-
There are no files associated with this item.
- Appears in Collections:
- Department of Brain Sciences Theses Master
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.