Hak Yeong Kim. (2020). The role of the posterior parietal cortex in visually-evoked defensive response. doi: 10.22677/Theses.200000286223
Type
Thesis
Description
Posterior parietal cortex, Zona incerta, Defense, Innate fear, Cognitive function
Table Of Contents
I. INTRODUCTION 1 1.1 Defensive behavior 1 1.2 Looming disc stimuli 2 1.3 Posterior parietal cortex 3 II. MATERIALS AND METHODS 6 III. RESULTS 11 3.1. Validate the effectiveness of the looming disk paradigm 11 3.2. PPC ablation mice showed differences in pattern maintenance and adaptation compared to control mice 18 3.3. Chemogenetic inactivation of PPC changes the visually-evoked defensive response, similar to the Casp3-mediated ablation 22 3.4. Chemogenetic activation of PPC changes the visually-evoked defensive response 23 3.5. Behavioral characterization of mice after activation/inactivation of PPC by CNO administration 29 3.6. The monitoring of PPC upstream and downstream region using tracing experiments 31 3.7 Functional identification of ZI role in controlling visual-threat defense behavior by PPC 33 IV. DISCUSSION 40 V. REFERENCES 44 VI. SUMMARY (국문요약) 46
