Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 유성운 | - |
| dc.contributor.author | Ye Won Lee | - |
| dc.date.accessioned | 2020-06-09T16:00:18Z | - |
| dc.date.available | 2020-06-09T16:00:18Z | - |
| dc.date.issued | 2020 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000281857 | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/11915 | - |
| dc.description | Autophagic cell death (ACD), Apoptosis, Corticosterone, Hippocampal neural stem (HCN) cells, Casein kinase 2 (CK 2), Caspase 9 | - |
| dc.description.statementofresponsibility | prohibition | - |
| dc.description.tableofcontents | Ⅰ. Introduction 1 Ⅱ. Material and Methods 11 2.1 Reagents and antibodies 11 2.2 Cell culture 11 2.3 Transfection, Expression vectors 12 2.4 Cell death assay 13 2.5 Western blotting 13 2.6 Caspase-9 activity assay 15 2.7 Immunocytochemistry 16 2.8 Live cell imaging 16 2.9 Statistical analysis 17 Ⅲ. Results 18 3.1 CASP9 is activated upon CORT-induced ACD in HCN cells. 18 3.2 Genetic ablation of CASP9 impairs CORT-induced ACD. 21 3.3 Regulation of caspase-9 by phosphorylation 23 3.4 CK2 inhibition switches ACD to apoptosis in HCN cells. 25 3.5 The cell death switching is dependent on ACD. 28 Ⅳ. Discussion 31 Ⅴ. Reference 34 Abstract in Korean 39 |
- |
| dc.format.extent | 40 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.title | CK2-mediated phosphorylation of caspase-9 switches autophagic cell death to apoptosis in adult hippocampal neural stem cells following corticosterone treatment. | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/Theses.200000286669 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Brain and Cognitive Sciences | - |
| dc.contributor.coadvisor | Youngtae Jeong | - |
| dc.date.awarded | 2020-02 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.BM 이64 202002 | - |
| dc.date.accepted | 2020-01-20 | - |
| dc.contributor.alternativeDepartment | 뇌인지과학전공 | - |
| dc.embargo.liftdate | 2025-01-03 | - |
| dc.contributor.affiliatedAuthor | Jeong, Youngtae | - |
| dc.contributor.affiliatedAuthor | Lee, Ye Won | - |
| dc.contributor.affiliatedAuthor | Yu, Seong-Woon | - |
| dc.contributor.alternativeName | 이예원 | - |
| dc.contributor.alternativeName | 정영태 | - |
| dc.contributor.alternativeName | Seong-Woon Yu | - |
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