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Discovery of new epigenomics-based biomarkers and the early diagnosis of neurodegenerative diseases

Title
Discovery of new epigenomics-based biomarkers and the early diagnosis of neurodegenerative diseases
Authors
Lee, DavinChoi, Yoon HaSeo, JinsooKim, Jong KyoungLee, Sung-Bae
DGIST Authors
Seo, JinsooKim, Jong KyoungLee, Sung-Bae
Issue Date
2020-08
Citation
Ageing Research Reviews, 61, 101069
Type
Article
Article Type
Review
Author Keywords
Neurodegenerative diseasesiPSCOrganoidSingle-cell sequencingEpigenetic alterationTranscriptional alteration
Keywords
HISTONE DEACETYLASE INHIBITORAMYLOID PRECURSOR PROTEINALZHEIMERS-DISEASEAXONAL-TRANSPORTHUNTINGTONS-DISEASEDNA METHYLATIONCHROMATIN ACCESSIBILITYFRONTOTEMPORAL DEMENTIAPARKINSONS-DISEASECEREBRAL ORGANOIDS
ISSN
1568-1637
Abstract
Treatment options for many neurodegenerative diseases are limited due to the lack of early diagnostic procedures that allow timely delivery of therapeutic agents to affected neurons prior to cell death. While notable advances have been made in neurodegenerative disease biomarkers, whether or not the biomarkers discovered to date are useful for early diagnosis remains an open question. Additionally, the reliability of these biomarkers has been disappointing, due in part to the large dissimilarities between the tissues traditionally used to source biomarkers and primarily diseased neurons. In this article, we review the potential viability of atypical epigenetic and/or consequent transcriptional alterations (ETAs) as biomarkers of early-stage neurodegenerative disease, and present our perspectives on the discovery and practical use of such biomarkers in patient-derived neural samples using single-cell level analyses, thereby greatly enhancing the reliability of biomarker application. © 2020 The Authors
URI
http://hdl.handle.net/20.500.11750/12064
DOI
10.1016/j.arr.2020.101069
Publisher
Elsevier BV
Related Researcher
  • Author Lee, Sung Bae Laboratory of Neurodegenerative Diseases and Aging
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
Files:
Collection:
Department of Brain and Cognitive SciencesLaboratory of Aging Brain1. Journal Articles
Department of New BiologyLaboratory of Single-Cell Genomics1. Journal Articles
Department of Brain and Cognitive SciencesLaboratory of Neurodegenerative Diseases and Aging1. Journal Articles


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